TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.22.2.2
Glycine:Na+ symporter, GlyT1c (glycine/2Na+/1Cl- symporter)

Accession Number:P28572
Protein Name:NTGL aka GlyT1c aka SLC6A9
Length:638
Molecular Weight:71061.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Glycine, Na+, Cl-

Cross database links:

Genevestigator: P28572
eggNOG: maNOG11298
RefSeq: NP_446270.1   
Entrez Gene ID: 116509   
Pfam: PF00209   
KEGG: rno:116509   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015187 F:glycine transmembrane transporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0005515 F:protein binding
GO:0005283 F:sodium:amino acid symporter activity
GO:0006865 P:amino acid transport
GO:0006836 P:neurotransmitter transport

References (5)

[1] “Cloning, expression, and localization of a rat brain high-affinity glycine transporter.”  Guastella J.et.al.   1353889
[2] “Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors.”  Smith K.E.et.al.   1534013
[3] “Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene.”  Borowsky B.et.al.   8494645
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure.”  Borowsky B.et.al.   9786914

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAVAHGPVAT SSPEQNGAVP SEATKKDQNL TRGNWGNQIE FVLTSVGYAV GLGNVWRFPY 
61:	LCYRNGGGAF MFPYFIMLVF CGIPLFFMEL SFGQFASQGC LGVWRISPMF KGVGYGMMVV 
121:	STYIGIYYNV VICIAFYYFF SSMTHVLPWA YCNNPWNTPD CAGVLDASNL TNGSRPTALS 
181:	GNLSHLFNYT LQRTSPSEEY WRLYVLKLSD DIGDFGEVRL PLLGCLGVSW VVVFLCLIRG 
241:	VKSSGKVVYF TATFPYVVLT ILFVRGVTLE GAFTGIMYYL TPKWDKILEA KVWGDAASQI 
301:	FYSLGCAWGG LITMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL GFMANHLGVD 
361:	VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL GLGTQFCLLE TLVTAIVDEV 
421:	GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ AGIYWLLLMD NYAASFSLVV ISCIMCVSIM 
481:	YIYGHRNYFQ DIQMMLGFPP PLFFQICWRF VSPTIIFFIL IFTVIQYRPI TYNHYQYPGW 
541:	AVAIGFLMAL SSVICIPLYA LFQLCRTDGD TLLQRLKNAT KPSRDWGPAL LEHRTGRYAP 
601:	TTTPSPEDGF EVQPLHPDKA QIPIVGSNGS SRLQDSRI