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2.A.22.2.3
Neutral and cationic amino acid:Na+:Cl- symporter, B0+. The rat homologue (NP_001032633) transports basic and zwitterionic amino acids, but not proline, aspartic acid and glutamic acid (Uchiyama et al, 2008).

Accession Number:Q9UN76
Protein Name:ATB0+
Length:642
Molecular Weight:72153.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Neutral and cationic amino acids, Na+, Cl-

Cross database links:

Genevestigator: Q9UN76 Q9UN76
eggNOG: prNOG16041 COG0733
HEGENOM: HBG702834 HOG000116406
RefSeq: NP_009162.1   
Entrez Gene ID: 11254   
Pfam: PF00209   
Drugbank: Drugbank Link   
OMIM: 300306  phenotype
300444  gene
KEGG: hsa:11254    hsa:11254   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006865 P:amino acid transport
GO:0006520 P:cellular amino acid metabolic process
GO:0006836 P:neurotransmitter transport
GO:0009636 P:response to toxin
GO:0031526 C:brush border membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006811 P:ion transport

References (10)

[1] “Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).”  Sloan J.L.et.al.   10446133
[2] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Do allelic variants of SLC6A14 predispose to obesity?”  Tiwari H.K.et.al.   14660737
[5] “The SLC6A14 gene shows evidence of association with obesity.”  Suviolahti E.et.al.   14660752
[6] “Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).”  Sloan J.L.et.al.   10446133
[7] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Do allelic variants of SLC6A14 predispose to obesity?”  Tiwari H.K.et.al.   14660737
[10] “The SLC6A14 gene shows evidence of association with obesity.”  Suviolahti E.et.al.   14660752

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 
61:	RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 
121:	MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 
181:	GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 
241:	LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 
301:	SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF 
361:	AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 
421:	LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 
481:	CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 
541:	FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 
601:	RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE