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2.A.22.2.4
Gut epithelium absorptive neutral amino acid Na+- or K+-dependent transporter, CAATCH1 (electrogenic; Cl--independent. Substrates: L-proline-preferring + Na+; L-threonine-preferring + K+; also transports L-methionine) (CAATCH1 can also function as an amino acid-gated cation [Na+ and K+] channel.)

Accession Number:Q9U5A9
Protein Name:CAATCH1
Length:633
Molecular Weight:69934.00
Species:Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) [7130]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Neutral amino acids, Na+, K+

Cross database links:

Pfam: PF00209   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (1)

[1] “A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent.”  Feldman D.H.et.al.   10829035

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNDGQVNGGF ESSEPKMEPK RSSQISLPPA NNKAALDNID DTDLEAEPPE RMVWSNNIEF 
61:	LMSCIATSVG LGNVWRFPFI AYQNGGGAFL VPYVIVLLLV GKPVYYLECV LGQFSSRNSV 
121:	KVWSISPAMK GTGYAQAAGC GYILSYYVVI CGLCLYYLAM SFQATLPWAI CQPEWENCVP 
181:	SDPTLAASVN NITNGTSSAQ LYFLRTVLQQ SDGIEGGLGA PIWYLVLCLF IAWLMVFGVV 
241:	ARGVKSSGKA AYFLALFPYV VMITLFITTI ILPGATDGIL FFVTPQWAKL LELGVWYSAV 
301:	TQVFFSLTVC TGPIIMFSSY NGFRHNIYRD AWIVTTLDTF TSFLSGCTIF GILGNLAYEL 
361:	NSEVGDVVGA GGTSLAFISY PDAIAKTFQP QLFSVLFFLM MSVLGIGSSV ALLSTFNTLA 
421:	MDAFPRVPTV YMSAMTCSCG FLLGLVYCTP GGQYILELVD HYGGTFLVLF CAISELAGVF 
481:	WIYGLENLCL DIEFMLGKKT GAYWRLCWGV ITPAIMTTVF FYALLASNNL VFGDNYVYPT 
541:	AGYVSGYLML FLGMTFVPIG IGFSLYKYRT GTFSETIKKA FHSKPSWGPR SPRERREWMQ 
601:	FKAEAKALRQ KMNTSRVKHL WYSITGAYRR NIN