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2.A.22.2.5
Gut epithelium absorptive neutral amino acid, K+- and Na+-dependent transporter KAAT1 (electrogenic; Cl--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro.

Accession Number:O76188
Protein Name:KAAT1
Length:634
Molecular Weight:70239.00
Species:Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) [7130]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Neutral amino acids, K+, Na+

Cross database links:

Pfam: PF00209   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (1)

[1] “Cloning and characterization of a potassium-coupled amino acid transporter.”  Castagna M.et.al.   9560287

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNDGQVNGGF ESSEPKMEPK RSSQISLPPA NLKATMDNID DMDLEAEPPE RMVWSNNIEF 
61:	LMSCIATSVG LGNVWRFPFI AYQNGGGAFL VPYIIVLLLV GKPVYYLECV LGQFSSRNSV 
121:	KIWSISPAMK GTGYAQAVGC GYILSYYVVI CGLCLFYLAM SFQATLPWAI CQPEWENCVP 
181:	SDPTLAAGVG NITNGTSSAE LYFLRTVLQQ SDGIEGGLGA PIWYLVLCLF IAWLMVFGVV 
241:	ARGVKSSGKA AYFLALFPYV VMITLFITTV LLPGATDGIL FFVTPDWWKL LELGVWYAAI 
301:	TQVFFSLSVC TGAIIMFSSY NGFKQNVYRD ALIVTTLDTF TSFLSGCTIF GILGNLAYEL 
361:	NSDVGDVIGS GGTSLAFISY PDAIAKTFQP QLFSVLFFLM MSVLGIGSSV ALLSTLNTVV 
421:	MDAFPRVPTV YMSALSCTCG FLLGLVYCTP GGQFILELVD HYGGTFLVLF CAISELAGVF 
481:	WIYGLENLCL DIEFMMGKTT GFYWRLCWGI VTPGMMIIVF IYALLSFENL VFGDFYVYPV 
541:	AGYVAGYMML FLGIVLVPIG IVVTLYKYRT GNFRETVKKA FHSKPSWGPR SPRLRREWMQ 
601:	FRIEAKALRQ KMNTSRVKHL WYSITGAYRR NINK