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2.A.22.2.7
Acetylcholine/choline:Na+ symporter, Snf-6 (interacts with dystrophin which determines its localization to the neuromuscular junction) (Kim et al., 2004)

Accession Number:O76689
Protein Name:Sodium-dependent acetylcholine transporter
Length:714
Molecular Weight:80420.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Acetylcholine, Choline, Na+

Cross database links:

eggNOG: meNOG05836
HEGENOM: HBG382487
RefSeq: NP_497416.4   
Entrez Gene ID: 191768   
Pfam: PF00209   
KEGG: cel:M01G5.5   

Gene Ontology

GO:0030054 C:cell junction
GO:0005887 C:integral to plasma membrane
GO:0045211 C:postsynaptic membrane
GO:0005277 F:acetylcholine transmembrane transporter act...
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0030165 F:PDZ domain binding
GO:0015870 P:acetylcholine transport
GO:0015871 P:choline transport
GO:0040011 P:locomotion
GO:0007274 P:neuromuscular synaptic transmission
GO:0001504 P:neurotransmitter uptake
GO:0040017 P:positive regulation of locomotion

References (2)

[1] “SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans.”  Kim H.et.al.   15318222
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVSSNDPEQ RNGRGMASGN NVDMSLYPPF IKQLDAKLPD YTREGDIEYP FEEITGVGDE 
61:	NRIRGNWSNK SDYLLAVIGF TAGVGSFWKF PFLVFQHGGA AFLVPYLCML CLASLPMFFM 
121:	EMVLGQFSSS AAISVWKVVP LFKGIGFAQV TISGFFAVFF NIISAWTLFY LINSFSFSIP 
181:	WSNCANSWSG ENCTLGTRIQ CKEMNGTLLV NGSCIVEHAS SNETTVIPLH DLGSIPSLKY 
241:	FQNDVLMLSK GVDDFGTLNW YLGLCVLACW IAVFLCLFQG VKSSGKVVYV AVIVPFIILT 
301:	VLLTRLLTLD GSLAAVFYFL TPKWEILMDL HVWGEAAVQA FYSVSCCSGG LFTIASYSRF 
361:	HNNIYKDIWL VLIVDVIVSL VGCLLTFSAI GFTCYEFAIS LDKFHIRDGF HLVFVFLAEA 
421:	LAGVSVAPLY AGLFFIMILL VVHATQMFVV ETIVSSICDE YPERLRRNRR HVLTTVCALF 
481:	ILLSIPFCLS SGLFWMELLT QFVLTWPLVV IAFLECMAIN WVYGVDNMLD NAKWIVGYWP 
541:	PCYIFWKILF KFICPMVYLA ILCFLWLDWN SIQYESYQFP YWSILTAWCI ASFPLILIPI 
601:	VGIWQFCIAK GTITQKWWRV LYPDDAWGPA MAIHRAEKFP LQIPEARRLL LPPEVEIASS 
661:	RGVLQEEMPM SYDYNTSSAA DVRSNRSTGH GATDVRSVAA TNNTIPKFER ETAI