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2.A.22.3.1
Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order).  Selective inhibitors have been identified (Kragholm et al. 2013).

Accession Number:P48065
Protein Name:NTBE aka SLC6A12
Length:614
Molecular Weight:69368.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Betaine, Gamma-aminobutyric acid, Na+, Diaminobutyrate, Proline, Quinidine, Dimethylglycine, Glycine, Sarcosine

Cross database links:

COG0733
Genevestigator: P48065 P48065
HEGENOM: HBG702834 HOG000116406
RefSeq: NP_001116319.1    NP_001116320.1    NP_003035.3   
Entrez Gene ID: 6539   
Pfam: PF00209   
OMIM: 603080  gene
KEGG: hsa:6539    hsa:6539   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005332 F:gamma-aminobutyric acid:sodium symporter ac...
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006865 P:amino acid transport
GO:0006836 P:neurotransmitter transport
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005332 F:gamma-aminobutyric acid:sodium symporter activity
GO:0071474 P:cellular hyperosmotic response
GO:0009992 P:cellular water homeostasis
GO:0006811 P:ion transport
GO:0007269 P:neurotransmitter secretion
GO:0010033 P:response to organic substance
GO:0055085 P:transmembrane transport

References (10)

[1] “Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.”  Rasola A.et.al.   7589472
[2] “Cloning and expression of a betaine/GABA transporter from human brain.”  Borden L.A.et.al.   7861179
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.”  Rasola A.et.al.   7589472
[7] “Cloning and expression of a betaine/GABA transporter from human brain.”  Borden L.A.et.al.   7861179
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDGKVAVQEC GPPAVSWVPE EGEKLDQEDE DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW 
61:	RFPYLCYKNG GGAFFIPYFI FFFVCGIPVF FLEVALGQYT SQGSVTAWRK ICPLFQGIGL 
121:	ASVVIESYLN VYYIIILAWA LFYLFSSFTS ELPWTTCNNF WNTEHCTDFL NHSGAGTVTP 
181:	FENFTSPVME FWERRVLGIT SGIHDLGSLR WELALCLLLA WVICYFCIWK GVKSTGKVVY 
241:	FTATFPYLML VILLIRGVTL PGAYQGIIYY LKPDLFRLKD PQVWMDAGTQ IFFSFAICQG 
301:	CLTALGSYNK YHNNCYKDCI ALCFLNSATS FVAGFVVFSI LGFMSQEQGV PISEVAESGP 
361:	GLAFIAFPKA VTMMPLSQLW SCLFFIMLIF LGLDSQFVCV ECLVTASIDM FPRQLRKSGR 
421:	RELLILTIAV MCYLIGLFLV TEGGMYIFQL FDYYASSGIC LLFLSLFEVV CISWVYGADR 
481:	FYDNIEDMIG YRPWPLVKIS WLFLTPGLCL ATFLFSLSKY TPLKYNNVYV YPPWGYSIGW 
541:	FLALSSMVCV PLFVVITLLK TRGPFRKRLR QLITPDSSLP QPKQHPCLDG SAGRNFGPSP 
601:	TREGLIAGEK ETHL