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2.A.22.3.10
Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13)

Accession Number:Q9NSD5
Protein Name:Sodium- and chloride-dependent GABA transporter 2
Length:602
Molecular Weight:68009.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Cl-, Gamma-aminobutyric acid

Cross database links:

Genevestigator: Q9NSD5
eggNOG: COG0733
HEGENOM: HOG000116406
Entrez Gene ID: 6540   
Pfam: PF00209   
KEGG: hsa:6540   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005886 C:plasma membrane
GO:0005332 F:gamma-aminobutyric acid:sodium symporter activity
GO:0042165 F:neurotransmitter binding
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0007269 P:neurotransmitter secretion
GO:0055085 P:transmembrane transport

References (5)

[1] “Sequence and chromosomal assignment of a human novel cDNA: similarity to gamma-aminobutyric acid transporter.”  Gong Y.et.al.   11824941
[2] “Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.”  Christiansen B.et.al.   17502375
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSRVSGTTS NGETKPVYPV MEKKEEDGTL ERGHWNNKME FVLSVAGEII GLGNVWRFPY 
61:	LCYKNGGGAF FIPYLVFLFT CGIPVFLLET ALGQYTSQGG VTAWRKICPI FEGIGYASQM 
121:	IVILLNVYYI IVLAWALFYL FSSFTIDLPW GGCYHEWNTE HCMEFQKTNG SLNGTSENAT 
181:	SPVIEFWERR VLKISDGIQH LGALRWELAL CLLLAWVICY FCIWKGVKST GKVVYFTATF 
241:	PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL 
301:	GSYNKYHNNC YRDCIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI 
361:	AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPHVF RKKNRREVLI 
421:	LGVSVVSFLV GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAKRFYDNI 
481:	EDMIGYRPWP LIKYCWLFLT PAVCTATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS 
541:	SMVCIPAWSL YRLGTLKGPF RERIRQLMCP AEDLPQRNPA GPSAPATPRT SLLRLTELES 
601:	HC