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2.A.22.3.11
Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)

Accession Number:P48029
Protein Name:Sodium- and chloride-dependent creatine transporter 1
Length:635
Molecular Weight:70523.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Cl-, Creatine

Cross database links:

Genevestigator: P48029
eggNOG: COG0733
Entrez Gene ID: 6535   
Pfam: PF00209   
Drugbank: Drugbank Link   
KEGG: hsa:6535   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005887 C:integral to plasma membrane
GO:0005886 C:plasma membrane
GO:0015220 F:choline transmembrane transporter activity
GO:0005309 F:creatine:sodium symporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006600 P:creatine metabolic process
GO:0006936 P:muscle contraction

References (12)

[1] “Cloning, pharmacological characterization, and genomic localization of the human creatine transporter.”  Nash S.R.et.al.   7953292
[2] “The cloning and expression of a human creatine transporter.”  Sora I.et.al.   7945388
[3] “The genomic organization of a human creatine transporter (CRTR) gene located in Xq28.”  Sandoval N.et.al.   8661155
[4] “Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family.”  Barnwell L.F.et.al.   7622069
[5] “Identification, characterization and cloning of SLC6A8C, a novel splice variant of the creatine transporter gene.”  Martinez-Munoz C.et.al.   18515020
[6] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[9] “X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28.”  Hahn K.A.et.al.   11898126
[10] “X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8.”  Bizzi A.et.al.   12210795
[11] “High prevalence of SLC6A8 deficiency in X-linked mental retardation.”  Rosenberg E.H.et.al.   15154114
[12] “High frequency of creatine deficiency syndromes in patients with unexplained mental retardation.”  Lion-Francois L.et.al.   17101918

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPVGL GTPGGRLAVP PRETWTRQMD 
61:	FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 
121:	INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 
181:	CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL 
241:	ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 
301:	GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 
361:	SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 
421:	GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 
481:	TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV 
541:	YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 
601:	LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM