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2.A.22.3.12
Sodium- and chloride-dependent GABA transporter, Ine (Protein inebriated) (Protein receptor oscillation A)

Accession Number:Q9VR07
Protein Name:Sodium- and chloride-dependent GABA transporter ine
Length:943
Molecular Weight:103636.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Cl-, Gamma-aminobutyric acid

Cross database links:

eggNOG: COG0733
Entrez Gene ID: 33659   
Pfam: PF00209   
KEGG: dme:Dmel_CG1544   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0005034 F:osmosensor activity
GO:0009881 F:photoreceptor activity
GO:0042066 P:perineurial glial growth
GO:0047484 P:regulation of response to osmotic stress
GO:0019226 P:transmission of nerve impulse

References (10)

[1] “Identification and characterization of inebriated, a gene affecting neuronal excitability in Drosophila.”  Stern M.et.al.   1334137
[2] “Drosophila rosA gene, which when mutant causes aberrant photoreceptor oscillation, encodes a novel neurotransmitter transporter homologue.”  Burg M.G.et.al.   10876650
[3] “A neurotransmitter transporter encoded by the Drosophila inebriated gene.”  Soehnge H.et.al.   8917579
[4] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[5] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[6] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[7] “Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.”  Yager J.et.al.   11517334
[8] “The Drosophila inebriated-encoded neurotransmitter/osmolyte transporter: dual roles in the control of neuronal excitability and the osmotic stress response.”  Huang X.et.al.   11861562
[9] “In vivo properties of the Drosophila inebriated-encoded neurotransmitter transporter.”  Huang Y.et.al.   11880499
[10] “Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster.”  Koles K.et.al.   17893096

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAENKDVSQV LNTTPDQVVI NRAPPTGLAP LRHSQLSDSG AESCYEGDEQ ARLIRSSSSR 
61:	AHKFIIIPAT PGTPPGSGAV AGPLPFRQTS STTSLAAMAA ALHKQSPLRH TSVRTRPSSE 
121:	VLQPGQVLAN QPTAAVSTST VTFTIDDCNE EGDAIPAAAS VPAPVTMPAI SPTPATLTCT 
181:	TTTTMAGDSV AVSPLSMELK SRLGSHHSSM RSVVSGYLPG LSDSSGNLVG GVSMATSGLQ 
241:	APNPLYMQPQ ASLSGSSYHF HELAGNQIYS DVTSVRSLAS IGIGSTDGRK LVIRRVPTTA 
301:	NELFDMVNPQ TPPPLGVDDD DSYLDMSDET AQLKPRQQHW ANKMQFVLAC IGYSVGLGNV 
361:	WRFPYMCYKS GGGVFLVPYC IILFICSIPL LFMELSVGQY TGRGPIGALG QLCPLFKGAG 
421:	LASVVVSFLM STYYSVIIGY SIYYFFTSFK TEMPWIDCNN RWNTPDCWVP QRKGINASAP 
481:	DTSRTPSEEF FENKVLQISG GLEYPGMMRW ELFACLICAW LMVYFATWKS IKSSAKVRYF 
541:	TATFPFVLII ILMVRAVTLD GAAEGLRFFF RPKWSELKNA NVWINAASQN FNSLGITFGS 
601:	MISFASYNKY NNNILRDTVA VSAVNMITSL LVGIFAFSTL GNLALEQNTN VRDVIGDGPG 
661:	MIFVVYPQAM AKMPYAQLWA VMFFFMLLCL GLNSQFAIVE VVVTSIQDGF PRWIKRHLGY 
721:	HEIVVLFVCV ISCLFGMPNI IQGGIYYFQL MDHYAASVTI MFLAFCQMIA IAWFYGTGRL 
781:	SKNVKQMTGK APSFYLRSCW LVLGPCLLFA IWVLSLINYH EPTYHNGRYT YPDWAYGIGW 
841:	MFASFSLICI PGYAVINFLR SSGDTFWERI RNTLRPNIYE CKICGEHHCE HDYPEQEQFM 
901:	LAQEMATVYK PTNPHLLNLG QKCGYNAMQA SPSHAEAGGP CGQ