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2.A.22.3.3
The taurine:Na+ symporter, TauT or SLC6A6 (also transports β-alanine and γ-aminobutyric acid (GABA); Tomi et al., 2008; Anderson et al., 2009).

Accession Number:P31641
Protein Name:NTTA aka SLC6A6
Length:620
Molecular Weight:69830.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Taurine, Na+

Cross database links:

Genevestigator: P31641 P31641
eggNOG: prNOG18250 COG0733
HEGENOM: HBG702834 HOG000116406
RefSeq: NP_001127839.1    NP_003034.2   
Entrez Gene ID: 6533   
Pfam: PF00209   
OMIM: 186854  gene
KEGG: hsa:6533    hsa:6533   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005369 F:taurine:sodium symporter activity
GO:0006520 P:cellular amino acid metabolic process
GO:0006836 P:neurotransmitter transport
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006865 P:amino acid transport

References (8)

[1] “Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.”  Jhiang S.M.et.al.   8382624
[2] “Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.”  Ramamoorthy S.et.al.   8010975
[3] “Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.”  Miyamoto Y.et.al.   8654117
[4] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[5] “Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.”  Jhiang S.M.et.al.   8382624
[6] “Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.”  Ramamoorthy S.et.al.   8010975
[7] “Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.”  Miyamoto Y.et.al.   8654117
[8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG 
61:	LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF 
121:	SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK 
181:	SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR 
241:	STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 
301:	SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 
361:	DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 
421:	FLRKGYRREI FIAFVCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 
481:	WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN 
541:	WAIGLGWSLA LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS 
601:	RTVMNGALVK PTHIIVETMM