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2.A.22.3.4
Creatine:Na+ symporter

Accession Number:P31661
Protein Name:NTCR aka SLC6A8
Length:635
Molecular Weight:70484.00
Species:Oryctolagus cuniculus (Rabbit) [9986]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Creatine, Na+

Cross database links:

eggNOG: maNOG12013
RefSeq: NP_001075866.1   
Entrez Gene ID: 100009280   
Pfam: PF00209   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005309 F:creatine:sodium symporter activity
GO:0006836 P:neurotransmitter transport
GO:0006814 P:sodium ion transport

References (1)

[1] “A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression.”  Guimbal C.et.al.   8473283

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPAGL GAPGGCLAVP PRETWTRQMD 
61:	FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 
121:	INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 
181:	CVEIFRHEDC ANGSLANLTC DQLAERRSPV IEFWENKVLR LSGGLEVPGA LNSEVTLCLL 
241:	ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 
301:	RSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 
361:	SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 
421:	GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVQMAGMYVF QLFDYYSASG 
481:	TTLLWQAFWE CVAVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNIV 
541:	YYKPLVYNKT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPVWG 
601:	LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM