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2.A.22.3.5
Renal apical membrane creatine:Na2+:Cl- symporter (CRT) (Garcia-Delgado et al., 2007)

Accession Number:P28570
Protein Name:NTCH aka SLC6A8
Length:635
Molecular Weight:70632.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Creatine, Na+, Cl-

Cross database links:

Genevestigator: P28570
eggNOG: maNOG15888
RefSeq: NP_059044.1   
Entrez Gene ID: 50690   
Pfam: PF00209   
KEGG: rno:50690   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015220 F:choline transmembrane transporter activity
GO:0005309 F:creatine:sodium symporter activity
GO:0015881 P:creatine transport
GO:0006836 P:neurotransmitter transport
GO:0006814 P:sodium ion transport

References (1)

[1] “Primary structure and functional expression of a choline transporter expressed in the rat nervous system.”  Mayser W.et.al.   1633856

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PSKGDGPAGL GAPSSRLAVP PRETWTRQMD 
61:	FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 
121:	INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 
181:	CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 
241:	ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 
301:	GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 
361:	SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 
421:	GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 
481:	TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV 
541:	YYKPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 
601:	LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM