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2.A.22.3.6
γ-aminobutyric acid (GABA):Na+:Cl- symporter GAT-1 (stoichiometry = 1:2:1) (Jiang et al., 2005)

Accession Number:Q5J2D5
Protein Name:GABA transporter protein
Length:610
Molecular Weight:69313.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Gamma-butyric acid, Na+, Cl-

Cross database links:

eggNOG: meNOG05168
HEGENOM: HBG702834
RefSeq: NP_505873.2   
Entrez Gene ID: 191770   
Pfam: PF00209   
KEGG: cel:T03F7.1   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (3)

[1] “A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function.”  Jiang G.et.al.   15542610
[2] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVEATSVAER EQWSSWADFI MSCIGYAIGL GNVWRFPYLC YQNGGGAFLI PYCISLVFCG 
61:	APLFILETSW GQLMSVGGLG MFKICPIFKG VGIAAAVMAF WLNIYYIVVL SWAATYLYNS 
121:	FTMSDVPWKN CDHAWNTPNC RSEYVKIPCD SNRTIAEFFN VKVLTHDHIH EYKKQFFVGE 
181:	KMNWTVCSAA DLSVVSPVKE FWNHRVLGIS SGLENPGGIR WDLALFLLLV WIICYLCIFK 
241:	GVKWTGKVVY ITASFPYMML FCLLIRGLTL EGAGVGLEFY LKPDFSKLLE SKVWVDAVTQ 
301:	VFFSYGLGLG ALVALGSYNK FNNNVYKQAL TVCFVNSGTS VFAGFVIFSF IGFMATQQEK 
361:	SVAEVAQAGP GLLFLAYPSG ILQLPYTQFW SCLFFLMVLF LGVDSQFCTM EGFFTAIIDE 
421:	FPQIRRKKYG REIFVGVICV ISYLIGLTTV TEGGFYVFQL FDFYAASGWA LLWLLFFECI 
481:	AISWSLGIDR WYEHMKSMIG YYPSAWWKFC WVFATPSVCF GVLLFGLIKY QPLRIDAYNY 
541:	DYPVWGHIFG WFLSLSSMLC IPGYAIWIWF KTPGTVQEKI KLLCRPDIEI KGAMENAENL 
601:	ELVEDFQNAI