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2.A.22.3.7
The GABA transporter, GAT4 (single mutations render this transporter C1- independent) (Zomot et al., 2007)

Accession Number:Q8BWA7
Protein Name:Putative uncharacterized protein aka Slc6a11
Length:627
Molecular Weight:69961.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Gamma-butyric acid

Cross database links:

Genevestigator: Q8BWA7
RefSeq: NP_766478.1   
Entrez Gene ID: 243616   
Pfam: PF00209   
KEGG: mmu:243616   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005332 F:gamma-aminobutyric acid:sodium symporter ac...
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (2)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.”  Mural R.J.et.al.   12040188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN KVEFVLSVAG 
61:	EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF LETALGQFTS EGGITCWRRV 
121:	CPLFEGIGYA TQVIEAHLNV YYIIILAWAI FYLSNCFTTE LPWATCGHEW NTEKCVEFQK 
181:	LNFSNYSHVS LQNATSPVME FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK 
241:	GTKSTGKVVY VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 
301:	IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV LGFMAYEQGV 
361:	PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF LGLDSQFVCV ESLVTAVVDM 
421:	YPKVFRRGYR RELLILALSI ISYFLGLVML TEGGMYIFQL FDSYAASGMC LLFVAIFECV 
481:	CIGWVYGSNR FYDNIEDMIG YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT 
541:	YPAWGYGIGW LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 
601:	TVTVNDCEAK VKGDGTISAI TEKETHF