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2.A.22.4.1
High affinity tryptophan:Na+ symporter, TnaT (Androutsellis-Theotokis et al., 2003)

Accession Number:O50649
Protein Name:TnaT
Length:501
Molecular Weight:54750.00
Species:Symbiobacterium thermophilum [2734]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate tryptophan, Na+

Cross database links:

HEGENOM: HBG702834
RefSeq: YP_074271.1   
Entrez Gene ID: 2980189   
Pfam: PF00209   
BioCyc: STHE292459:STH442-MONOMER   
KEGG: sth:STH442   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (2)

[1] “Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum.”  Hirahara T.et.al.   1339259
[2] “Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.”  Ueda K.et.al.   15383646

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAQRDQWKS RSGFIFATIG AAVGLGNFWR FPFMAYQNGG GAFLLPYFVA LLTAGVPLMI 
61:	LEFGFGHKMR TATITAFKKL NRRFEWIGWW QITVPVVVVT FYSVIISWSL RYLIFSFTQA 
121:	WGDDPGTFFS SDFLGITSGP LELGGLRWGI FAAVAVVWFA NYYISAQGIS GGIEKACKIM 
181:	TPFLIVAMLI FVIRGITLPG ATYGLNYFLN PDFSKIMDPG VWVAAYSQVF FSTTLAVGVM 
241:	IAYASYVPED SDLANNAFIT VFANSSFDFM AGLAVFSTLG YAAVTAGVPF EEMAVAGPGV 
301:	AFVAFPKAIS MLPGPTWLQS LFGILFFSAL LLAGISSSIS QMESFASAVI DRFGVDRKKL 
361:	LGWFSLIGFA FSALFATGAG VHILDIVDHF VGSYAIAILG LVEAIVLGYI MGTARIREHV 
421:	NLTSDIRVGM WWDVLVKYVT PVLLGYNILS NFISEFREPY AGYPTGALVL FGWVVAIAMF 
481:	GTSLFMQWRS QQLDVTGGEV G