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2.A.22.5.2
The 11 TMS Na+-dependent tyrosine transporter, Tyt1 (Quick et al., 2006)

Accession Number:Q8RHM5
Protein Name:Tyt1
Length:438
Molecular Weight:48096.00
Species:Fusobacterium nucleatum subsp. nucleatum [76856]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate tyrosine, Na+

Cross database links:

HEGENOM: HBG702834
RefSeq: NP_602780.1   
Entrez Gene ID: 992301   
Pfam: PF00209   
BioCyc: FNUC190304:FN1989-MONOMER   
KEGG: fnu:FN1989   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (1)

[1] “Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.”  Kapatral V.et.al.   11889109

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDNSERKFQS KIGFILTCVG SAVGMANIWA FPYRVGKYGG AVFLLIYFMF IALFSYVGLS 
61:	AEYLIGRRAE TGTLGSYEYA WKDVGKGKLG YGLAYIPLLG SMSIAIGYAV IAAWVLRTFG 
121:	AAVTGKILEV DTAQFFGEAV TGNFVIMPWH IAVIVLTLLT LFAGAKSIEK TNKIMMPAFF 
181:	VLFFILAVRV AFLPGAIEGY KYLFVPDWSY LSNVETWINA MGQAFFSLSI TGSGMIVCGA 
241:	YLDKKEDIIN GALQTGVFDT IAAMIAAFVV IPASFAFGYP ASAGPSLMFM TIPEVFKQMP 
301:	FGQLLAILFF VSVVFAAISS LQNMFEVVGE SIQTRFKMTR KSVIVLLGII ALVIGIFIEP 
361:	ENKVGPWMDV VTIYIIPFGA VLGAISWYWI LKKESYMEEL NQGSKVTRSE IYHNVGKYVY 
421:	VPLVLVVFVL GVIYHGIG