TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.22.5.3
Neurotransmitter:sodium symporter of 455 aas, MhsT.  The x-ray structures of two occluded inward-facing states with bound Na+ ions and L-tryptophan have been solved (4US4; Malinauskaite et al. 2014).  These structures provide insight into the cytoplasmic release of Na+. The switch from outward- to inward-oriented states is centered on the partial unwinding of transmembrane helix 5, facilitated by a conserved GlyX9Pro motif that opens an intracellular pathway for water to access the Na+2 site. Solvation through this TMS 5 pathway may facilitate Na+ release from the Na+2 site to the inward-open state (Malinauskaite et al. 2014). TMS5 plays a role in the binding and release of Na+ from the Na+2 site and in mediating conformational changes (Stolzenberg et al. 2017).

Accession Number:Q9KDT3
Protein Name:Transporter
Length:453
Molecular Weight:48178.00
Species:Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [272558]
Number of TMSs:11
Substrate sodium ions, neurotransmitter

Cross database links:

Structure:
4US3   4US4     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSLKQQTGRE QWASRLGFIL AAMGSAVGLG NIWRFSYVTG ENGGAAFLLV YLGFIALIGI 
61:	PIVLAEFTIG RRAQSDAVGS FEKLAPGKPW KVAGLMGVAA GFLILSFYGV IAGWILFYLF 
121:	NYITGQLWSA PAEGFGGFFE GFIANPTLPL FWQALFMIAT IWIVAIGVKK GIERSNKILM 
181:	PLLGVLLIAL AIYSLTLGGA KEGLAFLFSP DWSALKDPGV YLAAISQAFF TLSLGMGALI 
241:	TYGSYVSKDS RLPGAAVSVA GLDTAFAIIA GIMIFPAVFA LGLSPSGGPG LVFVVLPDIF 
301:	DSIRLGPIVG IAFFILLGAA ALSSAVSLLE VPVAYFMRKF DWSRKQAAIT LGVIITLLGI 
361:	PSSLSFGVLG EVTIIPGLNI FDSVDFIASS VFLPLGGMII ALFIGWGWKT SDALAESDLT 
421:	DSVWGKLWIL SLRFIAPIAI LIVFLSAFQI FFN