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2.A.22.6.2
Synaptic vesicle neutral amino acid:Na+ symporter NTT4/XT1/BOAT3 (SLC6A17) (catalyzes uptake of neurotransmitters into presynaptic vesicles (Zaia and Reimer, 2009).

Accession Number:P31662
Protein Name:Ntt4
Length:727
Molecular Weight:81055.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Neutral amino acids, Na+

Cross database links:

Genevestigator: P31662
RefSeq: NP_001028251.1   
Entrez Gene ID: 613226   
Pfam: PF00209   
KEGG: rno:613226   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (2)

[1] “A rat brain cDNA encoding the neurotransmitter transporter with an unusual structure.”  Liu Q.-R.et.al.   8093354
[2] “Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain.”  el Mestikawy S.et.al.   8294906

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKNSKVTQR EHSNEHVTES VADLLALEEP VDYKQSVLNV AGETGGKQKV AEEELDAEDR 
61:	PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV PYLVLLIIIG IPLFFLELAV 
121:	GQRIRRGSIG VWHYVCPRLG GIGFSSCIVC LFVGLYYNVI IGWSVFYFFK SFQYPLPWSE 
181:	CPVIRNGTVA VVEPECEKSS ATTYFWYREA LDISNSISES GGLNWKMTVC LLVAWSIVGM 
241:	AVVKGIQSSG KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 
301:	AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV VFAVLGFKAN 
361:	IMNEKCVVEN AEKILGYLNS NVLSRDLIPP HVNFSHLTTK DYSEMYNVIM TVKEKQFSAL 
421:	GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT HFPASPFWSV MFFLMLINLG LGSMIGTMAG 
481:	ITTPIIDTFK VPKEMFTVGC CVFAFFVGLL FVQRSGNYFV TMFDDYSATL PLTVIVILEN 
541:	IAVAWIYGTK KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVSPPGYSA 
601:	WIKEEAAERY LYFPNWAMAL LITLIAVATL PIPVVFILRH FHLLSDGSNT LSVSYKKGRM 
661:	MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST SPLESSSHPN GRYGSGYLLA 
721:	STPESEL