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2.A.22.6.4
The neutral amino acid transporter, B0AT3 (Slc6a18); XT2 (55% identical to 2.A.22.6.3)

Accession Number:Q96N87
Protein Name:Sodium- and chloride-dependent transporter XTRP2
Length:628
Molecular Weight:70925.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Neutral amino acids

Cross database links:

Genevestigator: Q96N87 Q96N87
eggNOG: prNOG15700 COG0733
HEGENOM: HBG702834 HOG000116406
RefSeq: NP_872438.2   
Entrez Gene ID: 348932   
Pfam: PF00209   
OMIM: 610300  gene
KEGG: hsa:348932    hsa:348932   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006865 P:amino acid transport
GO:0006836 P:neurotransmitter transport
GO:0005886 C:plasma membrane
GO:0006811 P:ion transport
GO:0006970 P:response to osmotic stress
GO:0055085 P:transmembrane transport

References (10)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Mutations in SLC6A19, encoding B(0)AT1, cause Hartnup disorder.”  Kleta R.et.al.   15286787
[4] “A nonsense polymorphism (Y319X) of the solute carrier family 6 member 18 (SLC6A18) gene is not associated with hypertension and blood pressure in Japanese.”  Eslami B.et.al.   16340170
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Mutations in SLC6A19, encoding B(0)AT1, cause Hartnup disorder.”  Kleta R.et.al.   15286787
[9] “A nonsense polymorphism (Y319X) of the solute carrier family 6 member 18 (SLC6A18) gene is not associated with hypertension and blood pressure in Japanese.”  Eslami B.et.al.   16340170
[10] “Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters.”  Broer S.et.al.   19033659

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAHAPEPDPA ACDLGDERPK WDNKAQYLLS CIGFAVGLGN IWRFPYLCQT YGGGAFLIPY 
61:	VIALVFEGIP IFHVELAIGQ RLRKGSVGVW TAISPYLSGV GLGCVTLSFL ISLYYNTIVA 
121:	WVLWYLLNSF QHPLPWSSCP PDLNRTGFVE ECQGSSAVSY FWYRQTLNIT ADINDSGSIQ 
181:	WWLLICLAAS WAVVYMCVIR GIETTGKVIY FTALFPYLVL TIFLIRGLTL PGATKGLIYL 
241:	FTPNMHILQN PRVWLDAATQ IFFSLSLAFG GHIAFASYNS PRNDCQKDAV VIALVNRMTS 
301:	LYASIAVFSV LGFKATNDYE HCLDRNILSL INDFDFPEQS ISRDDYPAVL MHLNATWPKR 
361:	VAQLPLKACL LEDFLDKSAS GPGLAFVVFT ETDLHMPGAP VWAMLFFGML FTLGLSTMFG 
421:	TVEAVITPLL DVGVLPRWVP KEALTGLVCL VCFLSATCFT LQSGNYWLEI FDNFAASLNL 
481:	LMLAFLEVVG VVYVYGMKRF CDDIAWMTGR RPSPYWRLTW RVVSPLLLTI FVAYIILLFW 
541:	KPLRYKAWNP KYELFPSRQE KLYPGWARAA CVLLSLLPVL WVPVAALAQL LTRRRRTWRD 
601:	RDARPDTDMR PDTDTRPDTD MRPDTDMR