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2.A.22.6.5
solute carrier family 6, member 16

Accession Number:Q9GZN6
Protein Name:Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
Length:736
Molecular Weight:82200.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q9GZN6 Q9GZN6
eggNOG: COG0733 COG0733
HEGENOM: HOG000116406 HOG000116406
Entrez Gene ID: 28968   
Pfam: PF00209   
KEGG: hsa:28968    hsa:28968   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005622 C:intracellular
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0005326 F:neurotransmitter transporter activity

References (8)

[1] “Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family.”  Farmer M.K.et.al.   11112352
[2] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[3] “Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.”  Yu L.-R.et.al.   17924679
[4] “Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.”  Varela I.et.al.   21248752
[5] “Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family.”  Farmer M.K.et.al.   11112352
[6] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[7] “Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.”  Yu L.-R.et.al.   17924679
[8] “Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.”  Varela I.et.al.   21248752

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ VSAARVAEAQ 
61:	ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL LARPFWSSKT EYILAQVGFS 
121:	MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP 
181:	WIGGVGYSSF MVCFILGLYF NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT 
241:	TPSIYFWYQQ ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL 
301:	PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT GIGLGSVASL 
361:	ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA TVITHRCCER NAEILLKLIN 
421:	LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP QHIKSMVLRE VTECNIETQF LKASEGPKFA 
481:	FLSFVEAMSF LPPSVFWSFI FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV 
541:	GVFLLMFVCG LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI 
601:	LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE VLRPYPPWAL 
661:	LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS TSLPLSHQLT PSKEVQKEEI 
721:	LQVDETKYPS TCNVTS