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2.A.22.6.6
Sodium-dependent vesicular neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4/BOAT3) (Solute carrier family 6 member 17) (Hägglund et al. 2013).

Accession Number:Q9H1V8
Protein Name:Sodium-dependent neutral amino acid transporter SLC6A17
Length:727
Molecular Weight:81001.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate Na+, Neutral amino acids, Neurotransmitters

Cross database links:

Genevestigator: Q9H1V8
eggNOG: COG0733
HEGENOM: HOG000116406
Entrez Gene ID: 388662   
Pfam: PF00209   
KEGG: hsa:388662   

Gene Ontology

GO:0030054 C:cell junction
GO:0005887 C:integral to plasma membrane
GO:0008021 C:synaptic vesicle
GO:0030672 C:synaptic vesicle membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0032328 P:alanine transport
GO:0015816 P:glycine transport
GO:0015820 P:leucine transport
GO:0015824 P:proline transport

References (4)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The repertoire of solute carriers of family 6: identification of new human and rodent genes.”  Hoglund P.J.et.al.   16125675

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA VEEELDAEDR 
61:	PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV PYLVLLIIIG IPLFFLELAV 
121:	GQRIRRGSIG VWHYICPRLG GIGFSSCIVC LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE 
181:	CPVVRNGSVA VVEAECEKSS ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM 
241:	AVVKGIQSSG KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 
301:	AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV VFAVLGFKAN 
361:	IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK DYMEMYNVIM TVKEDQFSAL 
421:	GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT HFPASPFWSV MFFLMLINLG LGSMIGTMAG 
481:	ITTPIIDTFK VPKEMFTVGC CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN 
541:	IAVAWIYGTK KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA 
601:	WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT LSVSYKKGRM 
661:	MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST SPLETSGNPN GRYGSGYLLA 
721:	STPESEL