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2.A.23.1.1
Glutamate/aspartate:H+ symporter, GltP; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5).  GltP residues involved in substrate binding and transport have been identified, especially in transmembrane helices VII and VIII (Rahman et al. 2016).

Accession Number:P21345
Protein Name:GltP aka B4077
Length:437
Molecular Weight:47159.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate

Cross database links:

Genevestigator: P21345
EchoBASE: EB0400
EcoGene: EG10405
eggNOG: COG1301
HEGENOM: HBG739804
RefSeq: AP_004578.1    NP_418501.1   
Entrez Gene ID: 948591   
Pfam: PF00375   
BioCyc: EcoCyc:GLTP-MONOMER    ECOL168927:B4077-MONOMER   
KEGG: ecj:JW4038    eco:b4077   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0006835 P:dicarboxylic acid transport

References (6)

[1] “Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12.”  Wallace B.et.al.   1971622
[2] “Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12.”  Tolner B.et.al.   1551855
[3] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNIKFSLAW QILFAMVLGI LLGSYLHYHS DSRDWLVVNL LSPAGDIFIH LIKMIVVPIV 
61:	ISTLVVGIAG VGDAKQLGRI GAKTIIYFEV ITTVAIILGI TLANVFQPGA GVDMSQLATV 
121:	DISKYQSTTE AVQSSSHGIM GTILSLVPTN IVASMAKGEM LPIIFFSVLF GLGLSSLPAT 
181:	HREPLVTVFR SISETMFKVT HMVMRYAPVG VFALIAVTVA NFGFSSLWPL AKLVLLVHFA 
241:	ILFFALVVLG IVARLCGLSV WILIRILKDE LILAYSTASS ESVLPRIIEK MEAYGAPVSI 
301:	TSFVVPTGYS FNLDGSTLYQ SIAAIFIAQL YGIDLSIWQE IILVLTLMVT SKGIAGVPGV 
361:	SFVVLLATLG SVGIPLEGLA FIAGVDRILD MARTALNVVG NALAVLVIAK WEHKFDRKKA 
421:	LAYEREVLGK FDKTADQ