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2.A.23.1.2
Glutamate/aspartate:Na+ + H+ symporter

Accession Number:P24943
Protein Name:GltT
Length:421
Molecular Weight:45469.00
Species:Bacillus stearothermophilus [1422]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate, Na+, H+

Cross database links:

Pfam: PF00375   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0006835 P:dicarboxylic acid transport

References (4)

[1] “Characterization and functional expression in Escherichia coli of the sodium/proton/glutamate symport proteins of Bacillus stearothermophilus and Bacillus caldotenax.”  Tolner B.et.al.   1359385
[2] “Cation-selectivity of the L-glutamate transporters of Escherichia coli, Bacillus stearothermophilus and Bacillus caldotenax: dependence on the environment in which the proteins are expressed.”  Tolner B.et.al.   8596452
[3] “Purification and reconstitution of the glutamate carrier GltT of the thermophilic bacterium Bacillus stearothermophilus.”  Gaillard I.et.al.   8634258
[4] “Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus.”  Yernool D.et.al.   14596613

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRKIGLAWQI FIGLILGIIV GAIFYGNPKV ATYLQPIGDI FLRLIKMIVI PIVISSLVVG 
61:	VASVGDLKKL GKLGGKTIIY FEIITTIAIV VGLLAANIFQ PGTGVNMKSL EKTDIQSYVD 
121:	TTNEVQHHSM VETFVNIVPK NIFESLTKGD MLPIIFFSVM FGLGVAAIGE KGKPVLQFFQ 
181:	GTAEAMFYVT NQIMKFAPFG VFALIGVTVS KFGVESLIPL SKLVIVVYAT MVFFIFVVLG 
241:	GVAKLFGINI FHIIKILKDE LILAYSTASS ETVLPKIMEK MENFGCPKAI TSFVIPTGYS 
301:	FNLDGSTLYQ ALAAIFIAQL YGIDMPISQQ ISLLLVLMVT SKGIAGVPGV SFVVLLATLG 
361:	TVGIPIEGLA FIAGIDRILD MARTAVNVIG NSLAAIIMSK WEGQYNEEKG KQYIAQLQQS 
421:	A