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2.A.23.1.7
Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase (Witan et al., 2012).  The interaction of DctA with DcuS has been studied extensively and reviewed (Unden et al. 2016).

Accession Number:P0A830
Protein Name:Aerobic C4-dicarboxylate transport protein
Length:428
Molecular Weight:45436.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Dicarboxylates

Cross database links:

Genevestigator: P0A830
EchoBASE: EB4140
EcoGene: EG20044
eggNOG: COG1301
HEGENOM: HOG000208775
DIP: DIP-47958N
Entrez Gene ID: 948039   
Pfam: PF00375   
KEGG: eco:b3528   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000299 C:integral to membrane of membrane fraction
GO:0005886 C:plasma membrane
GO:0015138 F:fumarate transmembrane transporter activity
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0015366 F:malate:hydrogen symporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0008643 P:carbohydrate transport
GO:0070778 P:L-aspartate transport
GO:0006974 P:response to DNA damage stimulus

References (6)

[1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Inactivation and regulation of the aerobic C(4)-dicarboxylate transport (dctA) gene of Escherichia coli.”  Davies S.J.et.al.   10482502
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[6] “Systems approach to refining genome annotation.”  Reed J.L.et.al.   17088549

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTSLFKSLY FQVLTAIAIG ILLGHFYPEI GEQMKPLGDG FVKLIKMIIA PVIFCTVVTG 
61:	IAGMESMKAV GRTGAVALLY FEIVSTIALI IGLIIVNVVQ PGAGMNVDPA TLDAKAVAVY 
121:	ADQAKDQGIV AFIMDVIPAS VIGAFASGNI LQVLLFAVLF GFALHRLGSK GQLIFNVIES 
181:	FSQVIFGIIN MIMRLAPIGA FGAMAFTIGK YGVGTLVQLG QLIICFYITC ILFVVLVLGS 
241:	IAKATGFSIF KFIRYIREEL LIVLGTSSSE SALPRMLDKM EKLGCRKSVV GLVIPTGYSF 
301:	NLDGTSIYLT MAAVFIAQAT NSQMDIVHQI TLLIVLLLSS KGAAGVTGSG FIVLAATLSA 
361:	VGHLPVAGLA LILGIDRFMS EARALTNLVG NGVATIVVAK WVKELDHKKL DDVLNNRAPD 
421:	GKTHELSS