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2.A.23.2.10
Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter)

Accession Number:Q10901
Protein Name:Excitatory amino acid transporter
Length:503
Molecular Weight:54676.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate, Na+

Cross database links:

eggNOG: COG1301
HEGENOM: HOG000208776
Entrez Gene ID: 180641   
Pfam: PF00375   
KEGG: cel:C12D12.2   

Gene Ontology

GO:0042995 C:cell projection
GO:0016021 C:integral to membrane
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity

References (5)

[1] “Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus.”  Radice A.D.et.al.   8885221
[2] “Molecular cloning of a cDNA for the glutamate transporter of the nematode Caenorhabditis elegans.”  Kawano T.et.al.   8920929
[3] “Structure and activity of a new form of the glutamate transporter of the nematode Caenorhabditis elegans.”  Kawano T.et.al.   9178573
[4] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[5] “Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.”  Fan X.et.al.   15888633

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPDTRINKE IMVSWIRKNL LLVLTVSSVV LGALCGFLLR GLQLSPQNIM YISFPGELLM 
61:	HMLKMMILPL IMSSLISGLA QLDARQSGKL GSLAVTYYMF TTAVAVVTGI FLVLVIHPGD 
121:	PTIKKEIGTG TEGKTVSTVD TLLDLLRNMF PENVVQATFQ QVQTKYIKVR PKVVKNNDSA 
181:	TLAALNNGSL DYVKASVEYT SGMNVLGVIV FCIAIGISLS QLGQEAHVMV QFFVIMDKVI 
241:	MKLVMTVMWY SPFGIFCLIM GKILEIHDLA DTARMLAMYM VTVLSGLAIH SLISLPLIFF 
301:	VTTKKNPYVF MRGLFQAWIT ALGTASSSAT LPITFNCLEE NLGVDRRVTR FVLPVGATIN 
361:	MDGTALYEAV AAIFIAQING VHLSFGQVVT VSLTATLASI GAASVPSAGL VTMLLVLTAV 
421:	GLPVKDVSLI VAVDWLLDRI RTSINVLGDA MGAGIVYHYS KADLDAHDRL AATTRSHSIA 
481:	MNDEKRQLAV YNSLPTDDEK HTH