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2.A.23.2.4
Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency (Besson et al., 2005).

Accession Number:Q8T0S9
Protein Name:dEaat2 aka CG3159-PB, isoform B
Length:371
Molecular Weight:40806.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate aspartate, Taurine, Na+, L-glutamate

Cross database links:

eggNOG: inNOG08262
Pfam: PF00375   

Gene Ontology

GO:0016020 C:membrane
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0005369 F:taurine:sodium symporter activity
GO:0006835 P:dicarboxylic acid transport
GO:0015734 P:taurine transport

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEMEKSGKFS DYLFAKMGPP TSTELPPKTT ECSDAPVELT GYRRWLSENL MLLVTLSGVL 
61:	
LGVILGLS LRPLNLHGDS IMLISYPGEL FMRVLKLMIL PLVISSLIAG SASLNAKMNG 
121:	KI
ALRTLV YFASTSFFNA ALGIALVLLI HPGNPDLHNA DDRSTDRRAV NLLDSLLDLG 
181:	RNVF
PDNL FQASIQQAHT VYLPKPSILH VFNETMNDTL ASGSEAQRLS EDLTEDVVLV 
241:	RDIQYR
SG TNTLGIVFFC LVFGTFLGTI GQKGQVVVDF FAAIFEVIMK MVTCVMWLTP 
301:	VGISSVIA
 GKILSVGDLG LVMSQLMWFI VTVAIGVFIY QFVVMQAIYF VVVRRNPFKF 
361:	YAGLIQAMLT 
AFATASTA AALPITFRCM NEKLKVDPRI TRFVLPIGCN INMDGTALYI 
421:	AVASIFIAQM SG
MVLGFG ELLTVLLTST AASMSSASVP SAALVLLLVV LTAIDAPVQD 
481:	VTLLFAVDWF VDRI
RTTN NMLGDCYTAA VVEELSRKEL MALDAASVNY QDMPAGTPNG 
541:	HGHGHGHHDG GLLEGQ
TE LETSSKCVMT MTDSVVVDIS AVMNNVNLQQ EHCNRRV