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2.A.23.2.7
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)

Accession Number:P43004
Protein Name:Excitatory amino acid transporter 2
Length:574
Molecular Weight:62104.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate, Na+

Cross database links:

Genevestigator: P43004
eggNOG: COG1301
Entrez Gene ID: 6506   
Pfam: PF00375   
Drugbank: Drugbank Link   
KEGG: hsa:6506   

Gene Ontology

GO:0030673 C:axolemma
GO:0043198 C:dendritic shaft
GO:0043197 C:dendritic spine
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0042734 C:presynaptic membrane
GO:0015501 F:glutamate:sodium symporter activity
GO:0005314 F:high-affinity glutamate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0030534 P:adult behavior
GO:0031668 P:cellular response to extracellular stimulus
GO:0070779 P:D-aspartate import
GO:0051938 P:L-glutamate import
GO:0035264 P:multicellular organism growth
GO:0010259 P:multicellular organismal aging
GO:0046326 P:positive regulation of glucose import
GO:0043200 P:response to amino acid stimulus
GO:0042493 P:response to drug
GO:0009611 P:response to wounding
GO:0007268 P:synaptic transmission
GO:0021537 P:telencephalon development
GO:0007632 P:visual behavior

References (9)

[1] “Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.”  Arriza J.L.et.al.   7521911
[2] “Molecular cloning of human brain glutamate/aspartate transporter II.”  Shashidharan P.et.al.   8172925
[3] “Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas.”  Manfras B.J.et.al.   7522567
[4] “DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.”  Shimamoto K.et.al.   9463476
[5] “Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript.”  Kim S.Y.et.al.   12950454
[6] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “A trimeric quaternary structure is conserved in bacterial and human glutamate transporters.”  Gendreau S.et.al.   15265858
[9] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.”  DeGiorgis J.A.et.al.   15822905

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC 
61:	GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 
121:	MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 
181:	VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM 
241:	NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI 
301:	IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG 
361:	TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL 
421:	DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS 
481:	VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA 
541:	AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK