TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.23.3.1
Neutral amino acid (alanine, serine, cysteine, threonine):Na+ symporter. Also transports homocysteine (Jiang et al., 2007). AscT1 is the Syncytin-1 (Q9UQF0) receptor. Syncytin-1, of 538 aas with 4-7 TMSs, is a viral fusion protein and is involved in the development of multiple sclerosis (Antony et al. 2007). Mutation causes nuerological problems including global developmental delay, severe progressive microcephaly, seizures, spasticity and thin corpus callosum (CC) (Heimer et al. 2015).

Accession Number:P43007
Protein Name:SATT aka AscT1 aka SLC1A4
Length:532
Molecular Weight:55723.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Alanine, Serine, Cysteine, Threonine, Na+

Cross database links:

Genevestigator: P43007 P43007
eggNOG: prNOG13947 COG1301
HEGENOM: HBG739804 HOG000208776
RefSeq: NP_001129053.1    NP_003029.2   
Entrez Gene ID: 6509   
Pfam: PF00375   
Drugbank: Drugbank Link   
OMIM: 600229  gene
KEGG: hsa:6509    hsa:6509   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005882 C:intermediate filament
GO:0042470 C:melanosome
GO:0005254 F:chloride channel activity
GO:0015180 F:L-alanine transmembrane transporter activity
GO:0015184 F:L-cystine transmembrane transporter activity
GO:0034590 F:L-hydroxyproline transmembrane transporter ...
GO:0015193 F:L-proline transmembrane transporter activity
GO:0015194 F:L-serine transmembrane transporter activity
GO:0015195 F:L-threonine transmembrane transporter activity
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0050890 P:cognition
GO:0006835 P:dicarboxylic acid transport
GO:0034589 P:hydroxyproline transport
GO:0015808 P:L-alanine transport
GO:0015811 P:L-cystine transport
GO:0015825 P:L-serine transport
GO:0015824 P:proline transport
GO:0035249 P:synaptic transmission, glutamatergic
GO:0015826 P:threonine transport
GO:0015186 F:L-glutamine transmembrane transporter activity
GO:0034590 F:L-hydroxyproline transmembrane transporter activity

References (17)

[1] “Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.”  Arriza J.L.et.al.   8101838
[2] “Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.”  Shafqat S.et.al.   8340364
[3] “Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.”  Hofmann K.et.al.   7896285
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[7] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[9] “Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.”  Arriza J.L.et.al.   8101838
[10] “Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.”  Shafqat S.et.al.   8340364
[11] “Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.”  Hofmann K.et.al.   7896285
[12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[13] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[16] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[17] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA 
61:	ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY 
121:	FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP 
181:	SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL 
241:	GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA 
301:	SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN 
361:	GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA 
421:	AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK 
481:	ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL