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2.A.23.3.2
Insulin-activated amino acid (serine, alanine, glutamate and others):Na+ symporter. Also transports homocysteine (Jiang et al., 2007).

Accession Number:P51912
Protein Name:AAAX aka SLC1A2 aka SLC1A7 aka ASCT2 aka AAAT
Length:553
Molecular Weight:58483.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Serine, Alanine, glutamate, Na+, Homocysteine

Cross database links:

Genevestigator: P51912
eggNOG: maNOG13505
Pfam: PF00375   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042470 C:melanosome
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0017153 F:sodium:dicarboxylate symporter activity
GO:0006835 P:dicarboxylic acid transport

References (2)

[1] “Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes.”  Liao K.et.al.   7702599
[2] “Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter.”  Utsunomiya-Tate N.et.al.   8662767

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVDPPKADP KGVAVDSSRR CPALGSREDQ SAKAGGCCGS RDRVRRCIRA NLLVLLTVAA 
61:	VVAGVGLGLG VSAAGGADAL GPARLTRFAF PGELLLRLLK MIILPLVVCS LIGGAASLDP 
121:	SALGRVGAWA LLFFLVTTLL ASALGVGLAL ALKPGAAVTA ITSINDSVVD PCARSAPTKE 
181:	ALDSFLDLVR NIFPSNLVSA AFRSFATSYE PKDNSCKIPQ SCIQREINST MVQLLCEVEG 
241:	MNILGLVVFA IVFGVALRKL GPEGELLIRF FNSFNDATMV LVSWIMWYAP VGILFLVASK 
301:	IVEMKDVRQL FISLGKYILC CLLGHAIHGL LVLPLIYFLF TRKNPYRFLW GIMTPLATAF 
361:	GTSSSSATLP LMMKCVEEKN GVAKHISRFI LPIGATVNMD GAALFQCVAA VFIAQLNGVS 
421:	LDFVKIITIL VTATASSVGA AGIPAGGVLT LAIILEAVSL PVKDISLILA VDWLVDRSCT 
481:	VLNVEGDAFG AGLLQSYVDR TKMPSSEPEL IQVKNEVSLN PLPLATEEGN PLLKQYQGPT 
541:	GDSSATFEKE SVM