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2.A.28.1.3
The organic anion:Na+ symporter, SOAT (transports estrone-3-sulfate (Km= 31 μM) and dehydropiandrosterone sulfate (Km = 30 μM) but not taurocholate, estradiol-17β-glucuronide or ouabain) (Geyer et al., 2004)

Accession Number:Q70EX6
Protein Name:Sodium-dependent organic anion transporter aka SOAT
Length:370
Molecular Weight:40310.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Na+, Estrone-3-sulfate, Dehydroepiandrosterone sulfate

Cross database links:

Genevestigator: Q70EX6
eggNOG: roNOG06876
RefSeq: NP_932166.1   
Entrez Gene ID: 289459   
Pfam: PF01758   
KEGG: rno:289459   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008508 F:bile acid:sodium symporter activity
GO:0043250 F:sodium-dependent organic anion transmembran...
GO:0006814 P:sodium ion transport
GO:0043251 P:sodium-dependent organic anion transport

References (1)

[1] “Identification of a sodium-dependent organic anion transporter from rat adrenal gland.”  Geyer J.et.al.   15020217

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSADCEGNST CPANSTEEDP PVGMEGQGSL KLVFTVLSAV MVGLVMFSFG CSVESRKLWL 
61:	HLRRPWGIAV GLLCQFGLMP LTAYLLAIGF GLKPFQAIAV LIMGSCPGGT VSNVLTFWVD 
121:	GDMDLSISMT TCSTVAALGM MPLCLYVYTR SWTLPQSLTI PYQSIGITLV SLVVPVASGI 
181:	YVNYRWPKQA TFILKVGAAV GGMLLLVVAV TGVVLAKGWN IDVTLLVISC IFPLVGHVMG 
241:	FLLAFLTHQS WQRCRTISIE TGAQNIQLCI AMMQLSFSAE YLVQLLNFAL AYGLFQVLHG 
301:	LLIVAAYQAY KRRQKSQYRR QHPECQDISS EKQPRETSAF LDKGAEAAVT LGLEQHHRTA 
361:	ELTSHVPSCE