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2.A.28.1.4
The organic anion:Na+ symporter, SOAT (probable paralogue of 2.A.28.1.3); a 7 TMS protein with the N-terminus out and the C-terminus in. Transports dehydroepiandrosterone sulfate, estrone-3-sulfate, and pregnenolone sulfate with Km values of 30, 12 and 11 μM, respectively. Sulfoconjugated taurolithocholate is also a substrate. Cholate, taurocholate and chenodeoxycholate are not substrates. (Geyer et al., 2007).

Accession Number:Q3KNW5
Protein Name:Solute carrier family 10 member 6
Length:377
Molecular Weight:41259.00
Species: [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Na+, Dehydroepiandrosterone sulfate, Estrone-3-sulfate, Pregnenolone sulfate, Sulfoconjugated taurolithocholate

Cross database links:

Genevestigator: Q3KNW5 Q3KNW5
eggNOG: prNOG12687 COG0385
HEGENOM: HBG714579 HOG000234524
RefSeq: NP_932069.1   
Entrez Gene ID: 345274   
Pfam: PF01758   
KEGG: hsa:345274    hsa:345274   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008508 F:bile acid:sodium symporter activity
GO:0006814 P:sodium ion transport
GO:0043250 F:sodium-dependent organic anion transmembrane transporter activity
GO:0043251 P:sodium-dependent organic anion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).”  Geyer J.et.al.   17491011
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).”  Geyer J.et.al.   17491011
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG CSVEIRKLWS 
61:	HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV LIMGCCPGGT ISNIFTFWVD 
121:	GDMDLSISMT TCSTVAALGM MPLCIYLYTW SWSLQQNLTI PYQNIGITLV CLTIPVAFGV 
181:	YVNYRWPKQS KIILKIGAVV GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT 
241:	GFLLALFTHQ SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID 
301:	GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE GAITPGPPGP 
361:	MDCHRALEPV GHITSCE