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2.A.28.1.7
Solute carrier family 10 (sodium/bile acid cotransporter family), member 4.  The rat orthologue is found in cholinergic neurons of the brain together with the vesicular acetyl choline transporter, VAChT (TC# 2.A.1.2.28), and the high affinity choline transporter, CHT1 (TC#s 2.A.21.8.1 & 2) (Geyer et al. 2008).  It is a protease-activated bile acid transporter (Abe et al. 2013).  It has also been reported to be a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo, and it may play a role in neurotransmitter release at the neuromuscular junction (Larhammar et al. 2015; Patra et al. 2015). It's loss in mice results in cognitive impairment (Melief et al. 2016).

Accession Number:Q96EP9
Protein Name:Sodium/bile acid cotransporter 4
Length:437
Molecular Weight:46504.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bile acids, Na+

Cross database links:

Genevestigator: Q96EP9 Q96EP9
eggNOG: COG0385 COG0385
HEGENOM: HOG000234524 HOG000234524
Entrez Gene ID: 201780   
Pfam: PF01758   
KEGG: hsa:201780    hsa:201780   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008508 F:bile acid:sodium symporter activity

References (2)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL GPGPSFGFSP 
61:	GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP LNHGLNVFVG AALCITMLGL 
121:	GCTVDVNHFG AHVRRPVGAL LAALCQFGLL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG 
181:	NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT 
241:	LCSTLIPIGL GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV 
301:	YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPQFIGSM 
361:	YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE DTDISYKKLK EEEMADTSYG 
421:	TVKAENIIMM ETAQTSL