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2.A.28.1.9
Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein; Na+/bile acid cotransporter; Na+/taurocholate transport protein; NTCP; Solute carrier family 10 member 1). Transports steroids and xenobiotics, including HMG-CoA reductase inhibiitors (statins). This protein is the hepatitis B and D virus receptor (Yan et al. 2012). Specific inhibitors are known (Slijepcevic and van de Graaf 2017).

Accession Number:Q14973
Protein Name:Sodium/bile acid cotransporter
Length:349
Molecular Weight:38119.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bile acids, xenobiotics, statins, steroids, taurocholate, bile conjugates

Cross database links:

Genevestigator: Q14973
eggNOG: COG0385
HEGENOM: HOG000234524
Entrez Gene ID: 6554   
Pfam: PF01758   
KEGG: hsa:6554   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0008508 F:bile acid:sodium symporter activity
GO:0008206 P:bile acid metabolic process
GO:0015711 P:organic anion transport

References (2)

[1] “Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.”  Hagenbuch B.et.al.   8132774
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK IKAHLWKPKG 
61:	LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP GGNLSNVFSL AMKGDMNLSI 
121:	VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR 
181:	PQYMRYVIKG GMIIILLCSV AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL 
241:	SALFCLNGRC RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL 
301:	IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA