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2.A.28.3.1
Solute carrier family 10, member 7 protein (358 aas; 10 established TMSs with the N- and C-termini in the cytoplasm (Godoy et al. 2007)) (Zou et al., 2005).  Present in the plasma membrane.  Slc10a7 KO mice exhibit moderate skeletal dysplasia (osteochondrodyplasia), characterized by markedly shortened and mildly bowed limbs (Brommage et al. 2014).

Accession Number:Q0GE19
Protein Name:Sodium/bile acid cotransporter 7
Length:358
Molecular Weight:39485.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q0GE19 Q0GE19
eggNOG: prNOG11469 COG0385
RefSeq: NP_001025169.1    NP_115504.1   
Entrez Gene ID: 84068   
Pfam: PF01758    PF13593   
OMIM: 611459  gene
KEGG: hsa:84068    hsa:84068   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008508 F:bile acid:sodium symporter activity
GO:0006814 P:sodium ion transport
GO:0015293 F:symporter activity

References (10)

[1] “Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family.”  Zou X.et.al.   15932064
[2] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family.”  Zou X.et.al.   15932064
[7] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 
61:	EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 
121:	AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP 
181:	LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI 
241:	IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI 
301:	SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE YLSIKFGH