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2.A.29.1.10
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Accession Number:P12236
Protein Name:ADP/ATP translocase 3
Length:298
Molecular Weight:32866.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Adenine

Cross database links:

Genevestigator: P12236 P12236
eggNOG: NOG238123 NOG238123
Entrez Gene ID: 293   
Pfam: PF00153   
Drugbank: Drugbank Link   
KEGG: hsa:293    hsa:293   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005744 C:mitochondrial inner membrane presequence translocase complex
GO:0005471 F:ATP:ADP antiporter activity
GO:0005488 F:binding
GO:0046732 P:active induction of host immune response by virus
GO:0006915 P:apoptotic process
GO:0006112 P:energy reserve metabolic process
GO:0050796 P:regulation of insulin secretion
GO:0044281 P:small molecule metabolic process
GO:0019058 P:viral infectious cycle
GO:0044267 P:cellular protein metabolic process
GO:0006626 P:protein targeting to mitochondrion

References (20)

[1] “DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.”  Cozens A.L.et.al.   2541251
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.”  Houldsworth J.et.al.   2829183
[4] “Study of PTPC composition during apoptosis for identification of viral protein target.”  Verrier F.et.al.   15033708
[5] “Mitochondrial membrane permeabilization by HIV-1 Vpr.”  Deniaud A.et.al.   16120388
[6] “Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.”  Zamarin D.et.al.   16201016
[7] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[8] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[9] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[10] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[11] “DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.”  Cozens A.L.et.al.   2541251
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[13] “Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.”  Houldsworth J.et.al.   2829183
[14] “Study of PTPC composition during apoptosis for identification of viral protein target.”  Verrier F.et.al.   15033708
[15] “Mitochondrial membrane permeabilization by HIV-1 Vpr.”  Deniaud A.et.al.   16120388
[16] “Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.”  Zamarin D.et.al.   16201016
[17] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[18] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[19] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[20] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR 
61:	IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG 
121:	GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS 
181:	VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM 
241:	QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI