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2.A.29.1.8
Mitochondrial ADP/ATP carrier.

Accession Number:Q9H0C2
Protein Name:ADP/ATP translocase 4
Length:315
Molecular Weight:35022.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate ADP, ATP

Cross database links:

Genevestigator: Q9H0C2 Q9H0C2
eggNOG: prNOG13050 NOG238123
HEGENOM: HBG610399 HOG000165727
RefSeq: NP_112581.1   
Entrez Gene ID: 83447   
Pfam: PF00153   
OMIM: 610796  gene
KEGG: hsa:83447    hsa:83447   

Gene Ontology

GO:0005929 C:cilium
GO:0019861 C:flagellum
GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport
GO:0005739 C:mitochondrion

References (12)

[1] “A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.”  Dolce V.et.al.   15670820
[2] “Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.”  Kim Y.-H.et.al.   17137571
[3] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[7] “A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.”  Dolce V.et.al.   15670820
[8] “Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.”  Kim Y.-H.et.al.   17137571
[9] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[10] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV QASSKQISPE 
61:	ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN FAFKDKYKQL FMSGVNKEKQ 
121:	FWRWFLANLA SGGAAGATSL CVVYPLDFAR TRLGVDIGKG PEERQFKGLG DCIMKIAKSD 
181:	GIAGLYQGFG VSVQGIIVYR ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS 
241:	YPFDTVRRRM MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL 
301:	YDKIKEFFHI DIGGR