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TCID	Name	Organismal Type	Example
2.A.29.1.1	Mitochondrial ATP/ADP antiporter (SLC25A5 (300150)). Facilitates exchange of ADP and ATP between the cytosol and mitochondria (inhibited by carboxyatractyloside and bongkrekate).	Animals	SLC25A5 of Homo sapiens
2.A.29.1.2	Mitochondrial ADP/ATP carrier 1 (AAC1); ADP/ATP translocase 1; adenine nucleotide translocator 1 (ANT1); adPEO, Sengers syndrome (SLC25A4)	Animals	SLC25A4 of Homo sapiens
2.A.29.1.3	ATP: ADP carrier AAC1 (one of three paralogues)	Fungi	AAC1 of Saccharomyces cerevisiae (P04710)
2.A.29.1.4	The Hydrogenosome ADP/ATP carrier (Van der Giezen et al., 2002)	Fungi	Hydrogenosome ADP/ATP carrier of Neocallimastix frontalis (AAK 71468)
2.A.29.1.5	ADP (Km = 40 然)/ATP (Km = 100 然) antiporter, ACC1 (three isoforms, AAC1, 2 and 3 were characterized where AAC3 has higher affinities (10-22 µM) (Haferkamp et al., 2002).	Plants	ACC1 of Arabidopsis thaliana (P31167)
2.A.29.1.6	The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008)	Plants	ER-ANT1 of Arabidopsis thaliana (Q0WQJ0)
2.A.29.1.7	ADP:ATP carrier 2, Aac2 (Lethal with loss of Sal1, (2.A.29.23.2) but independent of its AAC activity (Kucejova et al., 2008)).	Yeast	Aac2 of Saccharomyces cerevisiae (P18239)
2.A.29.1.8	Mitochondrial ADP/ATP carrier.	Animals	SLC25A31 of Homo sapiens
2.A.29.1.9	ADP/ATP carrier #3 (90% identical to 2.A.29.1.7) (#2)). Prolines in TMSs 1,3, and 5 are important for function (Babot et al., 2012).	Yeast	ADP/ATP exchanger of Saccharomyces cerevisiae (P18238)
2.A.29.1.10	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	Animals	SLC25A6 of Homo sapiens
2.A.29.2.1	Oxoglutarate/malate antiporter (also transports porphyrin derivatives: Fe-protoporphyrin IX, coproporphyrin III, hemin, etc.; Kabe et al., 2006)	Animals	Oxoglutarate/malate carrier of Bos taurus
2.A.29.2.2	Dicarboxylate (succinate/fumarate/ malate/α-ketoglutarate/ oxaloacetate) antiporter	Animals	Dicarboxylate transporter of Rattus norvegicus
2.A.29.2.3	Dicarboxylate:Pi antiporter (Pi, malate, succinate, oxaloacetate, sulfate, sulfite)	Yeast	Dicarboxylate:Pi antiporter of Saccharomyces cerevisiae
2.A.29.2.4	Mammalian oxodicarboxylate carrier (ODC; SLC25A21; 607571) (transports C5-C7 oxodicarboxylates including 2-oxoadipate and 2-oxoglutarate in an antiport reaction; also transports less well: pimelate, 2-oxopimleate, 2-amino adipate, oxaloacetate, and citrate) (Defects cause 2-oxoadipate acidemia, an inborn error of metabolism)	Animals	SLC25A21 of Homo sapiens
2.A.29.2.5	2-oxodicarboxylate carrier 2 (ODC2) (transports the same substrates as human ODC except that 2-amino adipate is not transported while malate is)	Yeast	ODC2 of Saccharomyces cerevisiae (Q99297)
2.A.29.2.6	Plant dicarboxylate/tricarboxylate carrier, DTC, transports dicarboxylates (such as malate, oxaloacetate, oxoglutarate, and maleate) and tricarboxylates (such as citrate, isocitrate, cis-aconitate, and trans-aconitate)	Plants	DTC of Nicotiana tabacum
2.A.29.2.7	Mitochondrial dicarboxylate carrier (DIC; SLC25A10; 606794) transports malate, succinate, phosphate, sulfate, thiosulfate	Animals	SLC25A10 of Homo sapiens
2.A.29.2.8	2-oxodicarboxylate carrier 1 (ODC1) transports C5-C7 oxodicarboxylic acid (2-oxoadipate, 2-oxoglularate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate) (functions by a strict antiport mechanism (Palmieri et al., 2001).	Yeast	ODC1 of Saccharomyces cerevisiae (Q03028)
2.A.29.2.9	The dicarboxylate carriers, DIC1 (transports malate, oxaloacetate and succinate as well as phosphate, sulphate and thiosulphate at high rates: 2-oxoglutarate is a poor substrate (Palmieri et al., 2007)).	Plants	DIC1 of Arabidopsis thaliana (Q9SJY5)
2.A.29.2.10	The dicarboxylate-tricarboxylate carrier (PfDTC) catalyzes oxoglutarate-malate, oxoglutarate-oxaloacetate, or oxoglutarate-oxoglutarate exchange (Nozawa et al., 2011).	Alveolata	DTC of Plasmodium falciparum (Q8IB73)
2.A.29.2.11	solute carrier family 25 (mitochondrial carrier; oxoglutarate/malate carrier), member 11	Animals	SLC25A11 of Homo sapiens (Q9CR62)
2.A.29.2.12	Solute carrier family 25 member 52 (Mitochondrial carrier triple repeat protein 2)	Animals	SLC25A52 of Homo sapiens
2.A.29.2.13	Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)	Animals	SLC25A11 of Homo sapiens
2.A.29.2.14	Solute carrier family 25 member 51 (Mitochondrial carrier triple repeat protein 1)	Animals	SLC25A51 of Homo sapiens
2.A.29.3.1	Uncoupling protein (H⁺; halide anions; protonated or anionic fatty acids)	Animals	Uncoupling carrier of Bos taurus
2.A.29.3.2	Mitochondrial brown fat uncoupling protein 1 (UCP1) (thermogenin); obesity protein (SLC25A7); mediates adaptive thermogenesis Azzu and Brand, 2009). Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012). Functions as a long-chain fatty acid (LCFA) anion/H⁺ symporter, but the LCFA anion can don dissociatedue to hydrophobic interactions, so it is, in effect, an H⁺carrier (Fedorenko et al. 2012).	Animals	UCP1 of Homo sapiens
2.A.29.3.3	The uncoupling protein, UCP1 or PUMP (functions to relieve oxidative stress, and to allow efficient photosynthesis (Sweetlove et al., 2006). In spome plants, it is activated in response to cold stress and may control reactive oxygen species (Valente et al. 2012).	Plants	UCP1 of Arabidopsis thaliana (O65623)
2.A.29.3.4	Human UCP2; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starving. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). Leucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca² uptake pathways (Waldeck-Weiermair et al., 2011). Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012). Reduces mitochondrial Ca²⁺ uptake in response to intracellular Ca²⁺release in pancreatic beta cells (Alam et al. 2012).	Animals	UCP2 of Homo sapiens
2.A.29.3.5	Human UCP3; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starving. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). It also modulates the activity of the sarco/endoplasmic reticulum Ca²-ATPase (SERCA) by decreasing mitochondrial ATP production (De Marchi et al., 2011).猂eucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca² uptake pathways (Waldeck-Weiermair et al., 2011).� Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).	Animals	UCP3 of Homo sapiens
2.A.29.4.1	Phosphate carrier	Animals, yeast	Phosphate carrier of Bos taurus
2.A.29.4.2	Phosphate carrier protein (PiC); mitochondrial precursor (PTP) (SLC25A3)	Animals	SLC25A3 of Homo sapiens
2.A.29.4.3	Phosphate carrier, Pic1: (PTP1; Mir1) (Hamel et al., 2004)	Yeast	Pic1 of Saccharomyces cerevisiae (P23641)
2.A.29.4.4	Phosphate carrier, Pic2: (PTP2; functionally equivalent paralogue of Pic1) (Hamel et al., 2004)	Yeast	Pic2 of Saccharomyces cerevisiae (P40035)
2.A.29.4.5	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	Animals	Phosphate carrier of Mus musculus (Q8VEM8)
2.A.29.4.6	Phosphate carrier-1, PiC1	Plants	PiC1 of Arabidopsis thaliana
2.A.29.5.1	MRS3 iron (Fe²⁺) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).	Yeast	MRS3 of Saccharomyces cerevisiae
2.A.29.5.2	MRS4 iron (Fe²⁺) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).	Yeast	MRS4 of Saccharomyces cerevisiae
2.A.29.5.3	Mitochondrial iron transporter, mitoferrin (Shaw et al., 2006). Essential for erythroid iron utilization (Froschauer et al. 2009). Mitochondrial iron import regulation occurs through differential turnover of mitoferrin 1 and mitoferrin 2 (Paradkar et al., 2009)	Animals	Mitoferrin of Brachydanio rerio (Q287T7)
2.A.29.5.4	solute carrier family 25 (mitochondrial iron transporter), member 28, putative iron transporter; Mitoferrin-2	Animals	Mitoferrin-2 of Mus musculus (Q8R0Z5)
2.A.29.5.5	solute carrier family 25 (mitochondrial iron transporter), member 37, putative iron transporter, Mitoferrin-1	Animals	Mitoferrin-1 of Mus musculus (Q920G8)
2.A.29.5.6	solute carrier family 25, member 38, SLC25A38; probably involved in heme biosynthesis by importing glycine and/or 5-aminolevulinate	Animals	SLC25A38 of Homo sapiens
2.A.29.5.7	Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37)	Animals	SLC25A37 of Homo sapiens
2.A.29.5.8	Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28)	Animals	SLC25A28 of Homo sapiens
2.A.29.6.1	Peroxisomal carrier	Yeast	Peroxysomal carrier of Candida boidinii
2.A.29.7.1	Tricarboxylate carrier (exchanges a tricarboxylate (citrate, isocitrate, cis-aconitate) + H⁺ for another tricarboxylate + H⁺, a dicarboxylate (malate, succinate) or phosphoenolpyruvate).	Animals	Citrate carrier of Rattus norvegicus
2.A.29.7.2	Citrate/malate exchange carrier CIC (CTP); tricarboxylate carrier (citrate·H⁺/malate, PEP) (SLC25A1)	Animals	SLC25A1 of Homo sapiens
2.A.29.7.3	Citrate transport protein, CTP1. Catalyzes obligatory exchange of the dibasic form of tricarboxylates (citrate and isocitrate) for other tricarboxylates. Two citrate binding sites per monomer have been identified (Ma et al., 2007). Mutations in residues in internal or external pore regions can relax the specificity, converting CTP1 into a nonspecific anion carrier. The data is consistent with outward-facing, occluded, and inward-facing states.	Yeast	CTP1 of Saccharomyces cerevisiae (P38152)
2.A.29.7.4	The fruit fly citrate uptake carrier, CIC (expressed at all stages of development; same substrate as for other eukaryotic tricarboxylate transporters (Carrisi et al., 2008).	Animals	CIC of Drosophila melanogaster (Q7KSQ0)
2.A.29.7.5	The citrate carrier (CIC) (Madeo et al., 2009)	Animals�	CIC of Anguilla anguilla (Q1ENH3)
2.A.29.8.1	Mitochondrial carnitine/acyl carnitine carrier (CAC)	Mammals	CAC of Rattus norvegicus
2.A.29.8.2	Embryonic differentiation (DIF-1) protein	Animals	DIF-1 of Caenorhabditis elegans
2.A.29.8.3	Human mitochondrial carnitine/acyl carnitine carrier; carnitine/acyl carnitine translocase (CACT). Defects in CACT (SLC25A20) cause CACT deficiency [MIM212138] (autosomal recessive; lethal) (Indiveri et al., 2011).	Animals	SLC25A20 of Homo sapiens
2.A.29.8.4	Carnitine carrier, CRC1	Yeast	CRC1 of Saccharomyces cerevisiae (Q12289)
2.A.29.8.5	The carnitine:acylcarnitine exchange translocase, CACL. CACL is similar in tissue distribution to that of CACT (TC# 2.A.29.8.3); both are expressed at a higher level in tissues using fatty acids as fuels, except the brain, where only CACL is expressed (Sekoguchi et al., 2003)	Animals	CACL of Homo sapiens (Q8BL03)
2.A.29.8.6	The mitochondrial basic amino acid transporter, in mBAC1 (transports the basic L-amino acids arginine, lysine, ornithine, and histidine in order of decreasing affinity; does not transport citrulline; expressed in stems, leaves, flowers, siliques, and seedlings; K_m for arg=0.2mM) (Hoyos et al., 2003)	Plants	mBAC1 of Arabidopsis thaliana (Q84UC7)
2.A.29.8.7	solute carrier family 25, member 45	Animals	SLC25A45 of Homo sapiens
2.A.29.8.8	solute carrier family 25, member 48	Animals	SLC25A48 of Homo sapiens
2.A.29.8.9	Mitochondrial carnitine/acylcarnitine carrier protein CACL (CACT-like) (Solute carrier family 25 member 29)	Animals	SLC25A29 of Homo sapiens
2.A.29.8.10	Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein)	Animals	SLC25A47 of Homo sapiens
2.A.29.8.11	Carrier protein YMC2, mitochondrial	Fungi	YMC2 of Saccharomyces cerevisiae
2.A.29.8.12	Carrier protein YMC1, mitochondrial	Fungi	YMC1 of Saccharomyces cerevisiae
2.A.29.9.1	Mitochondrial basic amino acid carrier (BAAC)	Fungi	BAAC of Neurospora crassa
2.A.29.9.2	Ornithine/arginine carrier, ORT1 or ARG11 (Palmieri et al., 1997)	Yeast	ORT1 of Saccharomyces cerevisiae (Q12375)
2.A.29.10.1	Flavin adenine dinucleotide (FAD) carrier (FADC; FLX1) (catalyzes FAD export from the mitochondrion) (Bafunno et al., 2004)	Yeast	FLX1 of Saccharomyces cerevisiae
2.A.29.10.2	Mitochondrial folate transporter, hMFT	Animals	SLC25A32 of Homo sapiens
2.A.29.10.3	Chloroplast folate/folate derivative transporter, AtFOLT1 (Bedhomme et al., 2005; Haferkamp and Schmitz-Esser 2012)	Plants	AtFOLT1 of Arabidopsis thaliana (CAH65737)
2.A.29.10.4	Mitochondrial pyrimidine nucleotide transporter, RIM2 (transports TTP (Km= 200 μM), UTP (Km= 400 μM) and CTP (Km= 440 μM). Catalyzes electroneutral TTP/TMP and TTP/TDP antiport. Deoxy pyrimidine nucleotides are also transported) (Marobbio et al., 2006). Pyrimidine trinucleotide transporter, RIM2 (transports TTP, CTP and UTP) (Todisco et al., 2006)	Yeast	RIM2 of Saccharomyces cerevisiae (P38127)
2.A.29.10.5	The mitochondrial NAD⁺ uptake transporter, Ndt1 (also transports (d)AMP and (d)GMP but not α-NAD⁺, NADH, NADP⁺, or NADPH. Transport is saturable with an apparent K_m of 0.38mM for NAD⁺). (70% identical to Ndt2 which also takes up NAD⁺). The main role of Ndt1p and Ndt2p is to import NAD⁺ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated (d)AMP and (d)GMP (Todisco et al., 2006)	Yeast	Ndt1 of Saccharomyces cerevisiae (P40556)
2.A.29.10.6	solute carrier family 25 (pyrimidine nucleotide carrier ), member 36	Animals	SLC25A36 of Homo sapiens
2.A.29.10.7	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	Animals	SLC25A33 of Homo sapiens
2.A.29.10.8	Mitochondrial nicotinamide adenine dinucleotide transporter 2 (Mitochondrial NAD(+) transporter 2)	Fungi	YEA6 of Saccharomyces cerevisiae
2.A.29.11.1	The Plastid (Amyloplast) ADP-glucose transporter Brittle endosperm 1 (BT1) (Kirchberger et al., 2007).	Plants	BT1 of Zea mays
2.A.29.11.2	The Adenine nucleotide uniporter, BT1 (Leroch et al., 2005).	Plants	BT1 of Solanum tuberosum (Q9ZNY4)
2.A.29.11.3	The plastid ADP-glucose transporter, Nst1 (~90% identical to and probably orthologous with 2.A.29.11.1.) (Haferkamp, 2007).	Plants	Nst1 of Hordeum vulgare (Q6E5A5)
2.A.29.11.4	Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser 2012).	Plants	ANT1 of Arabidopsis thaliana
2.A.29.12.1	Grave𠏋 disease carrier (GDC) protein (may transport coenzyme A or a coenzyme A precursor) (SLC25A16 for the human orthologue)	Mammals	GDC of Bos taurus
2.A.29.12.2	Mitcochondrial exchange transporter for Coenzyme A and adenosine 3', 5'-diphosphate, SLC25A42 (also transports dephospho-Coenzyme A, and ADP; Fiermonte et al. 2009).	Animals	SLC25A42 of Homo sapiens
2.A.29.12.3	solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16	Animals	SLC25A16 of Homo sapiens
2.A.29.12.4	Mitochondrial carrier protein LEU5	Fungi	LEU5 of Saccharomyces cerevisiae
2.A.29.13.1	Succinate/fumarate antiporter	Yeast	ACR1 of Saccharomyces cerevisiae
2.A.29.14.1	Mitochondrial Ca²⁺-activated aspartate/glutamate antiporter carrier with Ca²⁺-binding EF-hand domain, Aralar	Animals	SLC25A12 of Homo sapiens
2.A.29.14.2	Mitochondrial Ca²⁺-activated aspartate/glutamate antiporter carrier with Ca²⁺-binding EF-hand domain, Citrin (defects in humans cause type II citrullinemia)	Animals	SLC25A13 of Homo sapiens
2.A.29.14.3	Mitochondrial glutamate carrier 1 (GC1); glutamate:H⁺ symporter 1 (SLC25A22). Plays a role in glucose-stimulated insulin secretion by β-cells (Casimir et al., 2009).	Animals	SLC25A22 of Homo sapiens
2.A.29.14.4	Yeast mitochondrial aspartate/glutamate antiporter, Agc1 (Cavero et al., 2003) (also catalyzes glutamate uniport). Comprised of 902 aas; has a 500 residue N-terminal hydrophilic domain as well as a C-terminal 100 residue hydrophilic domain. Both domains are uniquely found in members of the 2.A.29.14 subfamily.	Yeast	Agc1 of Saccharomyces cerevisiae (NP_015346)
2.A.29.14.5	solute carrier family 25 (glutamate carrier), member 18	Animals	SLC25A18 of Homo sapiens
2.A.29.14.6	solute carrier family 25, member 40	Animals	SLC25A40 of Homo sapiens
2.A.29.14.7	solute carrier family 25, member 44	Animals	SLC25A44 of Homo sapiens
2.A.29.14.8	Solute carrier family 25 member 39	Animals	SLC25A39 of Homo sapiens
2.A.29.15.1	Oxaloacetate/malonate/sulfate/thiosulfate transporter, OAC1	Yeast	Oxaloacetate carrier (OAC1) of Saccharomyces cerevisiae
2.A.29.15.2	solute carrier family 25, member 35	Animals	SLC25A35 of Homo sapiens
2.A.29.15.3	solute carrier family 25, member 34	Animals	SLC25A34 of Homo sapiens
2.A.29.16.1	Reported to be a deoxynucleotide (enzyme), the deoxynucleotide carrier (DNT) (all four dNDPs and less efficiently, all four dNTPs are transported, but not dNMPs, NMPs or nucleosides). It is also a thiamin pyrophosphate (TPP) transporter responsible for Amish lethal microencephaly brain development retardation (MCPHA) and α-ketoglutarate acidurua when defective (Arco and Satrústegui, 2005; Lindhurst et al., 2006; Iacopetta et al., 2010).	Animals	SLC25A19 of Homo sapiens
2.A.29.16.2	The thiamin pyrophosphate (TPP) transporter, Tpc1; also transports pyrophosphate, ADP, ATP and other nucleotides (Iacopetta et al., 2010).	Animals	Tpc1 of Drosophila melanogaster (Q7K0L7)
2.A.29.16.3	Uncharacterized mitochondrial carrier C1604.04	Yeast	SPBC1604.04 of Schizosaccharomyces pombe
2.A.29.17.1	Peroxisomal ATP/ADP/AMP antiporter, Ant1 (Ypr128cp)	Yeast	Ant1 of Saccharomyces cerevisiae (AAB68270)
2.A.29.17.2	ADP/ATP-specific mitochondrial carrier (MC) in mitosomes (reduced mitochondria incapable of ATP synthesis) (Williams et al., 2008).	Microsporidian	MC in Antonospora locustae (Q4VFZ9)
2.A.29.18.1	Mitochondrial S-adenosylmethionine (SAM) carrier, Sam5p or PET8 (Marobbio et al., 2003)	Yeast	Sam5p of Saccharomyces cerevisiae (P38921)
2.A.29.18.2	The plastid S-Adenosylmethionine importer, SAMT1 (regulates plastid biogenesis and plant development; catalyzes the counter-exchange of SAM with SAM and with S-adenosylhomocysteine) (Bouvier et al., 2006). Also present in the mitochondrion (Haferkamp and Schmitz-Esser 2012).	Plants	SAMT1 of Arabidopsis thaliana (Q94AG6)
2.A.29.18.3	solute carrier family 25 (S-adenosylmethionine carrier), member 26	Animals	SLC25A26 of Homo sapiens
2.A.29.19.1	Mitochondrial ornithine carrier 2 (ORC2 or OrnT2) (transports ornithine, citrulline, lysine, arginine, histidine); HHH syndrome (SLC25A2). Catalyzes ornithine:citrulline antiport and ornithine:H⁺antiport (Tonazzi and Indiveri, 2011).	Animals	SLC25A2 of Homo sapiens
2.A.29.19.2	Mitochondrial ornithine transporter (ornithine/citruline exchanger), SLC25A15 or Orc1. Catalyzes a vital step in the urea cycle, interconnecting the cytosolic and mitochondrial components for the cycle (Moraes and Reithmeier 2012).	Animals	SLC25A15 of Homo sapiens
2.A.29.20.1	Peroxisomal adenine nucleotide carrier (ANC) (SLC25A17)	Animals	SLC25A17 of Homo sapiens
2.A.29.20.2	Peroxisomal adenine nucleotide carrier 2, PNC2. Transports ATP, ADP and NAD⁺ (Linka and Esser 2012).	Plants	PNC2 of Arabidopsis thaliana
2.A.29.20.3	Peroxisomal nucleotide (ATP, ADP, AMP) carrier-1, PNC1 (Haferkamp and Schmitz-Esser 2012).	Plants	PNC1 of Arabidopsis thaliana
2.A.29.21.1	Mitochondrial GTP/GDP exchange carrier (Ggc1) [also transports deoxyGTP and deoxyGDP as well as ITP and IDP but less well than GTP and GDP] [K_M(GTP)=1 μM; K_M(GDP)=5 μM]. Inhibited by pyridoxal-5-P, bathophenanthroline and tannic acid but not by inhibitors of the ATP-ADP carrier (Vozza et al., 2004).	Yeast	Ggc1 of Saccharomyces cerevisiae (NP_010083)
2.A.29.22.1	Hydrogenosome ATP/ADP antiporter, HMP31 (Tjaden et al., 2004)	Anaerobic flagellates	HMP31 of Trichomonas gallinae (AAP30846)
2.A.29.22.2	The Mitosome (crypton) ADP/ATP carrier (Chan et al., 2005)	amoeba	Mitosome ADP/ATP carrier of Entamoeba histolytica (AAK69775)
2.A.29.23.1	Mitochondrial ATP-Mg²⁺/inorganic phosphate antiporter [3 isoforms in humans with 3 EF-hand CA²⁺ binding motifs in their N-terminal domain: Q6KCM7, Q9BV35, and Q6NUK1] (Fiermonte et al., 2004)	Animals	SLC25A25 of Homo sapiens
2.A.29.23.2	Mg²⁺-ATP/Pi carrier, Sal1 (Ca²⁺ binding carrier, CMC1; supressor of AAC2 lethality (EF hand Ca²⁺ binding motif at N-terminus). ADP:ATP carrier 2 (Kucejova et al., 2008; Traba et al., 2008)	Yeast	Sal1 of Saccharomyces cerevisiae (P48233)
2.A.29.23.3	Chloroplast thylakoid ATP/ADP antiporter, TAAC (Thuswaldner et al., 2007; Haferkamp et al., 2011). Also transports 3'-phosphoadenosine 5'-phosphosulfate (PAPS), made in the mitochondria and exported to the cytoplasm where it is involved in several aspects of sulfur metabolism, including the biosynthesis of thiols, glucosinolates, and phytosulfokines, and therefore also named PAPST1 (Gigolashvili et al. 2012). Expression of the PAPST1 gene is regulated by the same MYB transcription factors that also regulate the biosynthesis of sulfated secondary metabolites, glucosinolates.	Plants	TAAC of Arabidopsis thaliana (Q9M024)
2.A.29.23.4	The mitochondrial adenine nucleotide transporter, ADNT1 (At4g01100) (prefers AMP and ADP to ATP; not inhibited by bongkrekate or carboxyatractyloside; loss yields reduced root growth and respiration) (Palmieri et al., 2008b).	Plants	ADNT1 of Arabidopsis thaliana (O04619)
2.A.29.23.5	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	Animals	SLC25A23 of Homo sapiens
2.A.29.23.6	solute carrier family 25, member 41	Animals	SLC25A41 of Homo sapiens
2.A.29.23.7	solute carrier family 25, member 43	Animals	SLC25A43 of Homo sapiens
2.A.29.23.8	Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1; Mitochondrial Ca(2 )-dependent solute carrier protein 1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24).	Animals	SLC25A24 of Homo sapiens
2.A.29.24.1	Brain mitochondrial carrier protein 1, BMCP1 (participates in mitochondrial proton leak) (also called uncoupling protein-5 (UCP5)) (Sanchis et al., 1998).� Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012).	Animals	SLC25A14 of Homo sapiens
2.A.29.24.2	Kidney mitochondrial carrier protein, KMCP1 (Haguenauer et al., 2005)	Animals	KMCP1 of Mus musculus (NP_080508)
2.A.29.24.3	solute carrier family 25, member 27; UCP4. Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012).	Animals	SLC25A27 of Homo sapiens
2.A.29.24.4	solute carrier family 25, member 30; Kidney MCP1	Animals	SLC25A30 of Homo sapiens
2.A.29.25.1	The mitochondrial presenilin-associated protein (PSAP; MTCH1) binds to the PDZ domain (a QFYI motif) C-terminus of presenilin. It contains 2 solcar repeats and is 389 aas long. It is most similar to 2.A.29.23.1 and 2.A.29.12.1. There are 2 human isoforms, mitochondrial carrier homologues, MTCH1 and MTCH2, possibly involved in apoptosis (Xu et al., 1999, 2002). Its transport function is unknown (Xu et al., 1999, 2002).	Animals	MTCH1 of Homo sapiens (Q9NZJ7)
2.A.29.25.2	The mitochondrial carrier homologue-2 (MTCH2). Binds the BH3-interacting domain death agonist, BID. Regulated (induced) by the hepatocyte growth factor receptor, HGF/SF or Met.	Animals	MTCH2 of Homo sapiens (Q9Y6C9)
2.A.29.26.1	Viral mitochondrial carrier-like protein, L276 (VMC) for dATP and dTTP (237 aas) (Monné et al., 2007).	Animal virus	VMC of Mimiviridae mimivirus (Q5UPV8)
2.A.29.27.1	The NAD/NADP transporter, NDT1 (S. cervisiae has two isoforms NDT1 and NDT2)	Yeast	NDT1 of Saccharomyces cerevisiae (P40556)
2.A.29.27.2	Chloroplastic (plastidic) NAD/NADPcarrier, NDT1; counter exchange substrates: ADP and AMP (Palmieri et al., 2009).	Plants	NDT1 of Arabidopsis thaliana (O22261)
2.A.29.27.3	Mitochondrial NAD/NADPcarrier, NDT2; counter exchange substrates include ADP and AMP (Palmieri et al., 2009).	Plants	NDT2 of Arabidopsis thaliana (Q8RWA5)
2.A.29.28.1	The thiamin pyrophosphate (TPP) carrier, TPC1 (Marobbio et al., 2002).	Yeast	TPC1 of Saccharomyces cerevisiae (NP_011610)
2.A.29.29.1	The citrate/oxoglutarate carrier, Yhm2 (Castegna et al., 2010; Mayor et al., 1997). Ymh2 also transports oxaloacetate, succinate, and fumarate, but not malate or isocitrate. It may function in antioxidation (Castegna et al., 2010).	Yeast	Yhm2 of Saccharomyces cerevisiae (Q04013)
2.A.29.30.1	The human mitochondrial carrier (418aas; 6 TMSs) of unknown function (SLC25A46)	Animals	SLC25A46 of Homo sapiens
2.A.29.31.1	The ATP exchanger/symporter, LcnP (secreted via the bacterial Dot/Icm type IV secretion system into macrophages, and assembled in the mitochondrial inner membrane (Dolezal et al., 2012)).	Bacteria	LcnP of Legionella pneumophila (Q5WSP6)