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2.A.29.10.4
Mitochondrial pyrimidine nucleotide transporter, RIM2 (transports TTP (Km= 200 μM), UTP (Km= 400 μM) and CTP (Km= 440 μM). Catalyzes electroneutral TTP/TMP and TTP/TDP antiport. Deoxy pyrimidine nucleotides are also transported) (Marobbio et al., 2006). Pyrimidine trinucleotide transporter, RIM2 (transports TTP, CTP and UTP) (Todisco et al., 2006)

Accession Number:P38127
Protein Name:Mitochondrial carrier protein RIM2
Length:377
Molecular Weight:42102.00
Species: [4932]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Pyrimidines, TTP, UTP, CTP, TMP, TDP

Cross database links:

Genevestigator: P38127
eggNOG: fuNOG05636
HEGENOM: HBG735918
DIP: DIP-4933N
RefSeq: NP_009751.1   
Entrez Gene ID: 852491   
Pfam: PF00153   
KEGG: sce:YBR192W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0015218 F:pyrimidine nucleotide transmembrane transpo...
GO:0000002 P:mitochondrial genome maintenance
GO:0006864 P:pyrimidine nucleotide transport
GO:0055085 P:transmembrane transport

References (3)

[1] “RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif.”  Demolis N.et.al.   8346681
[2] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKKSIEEWE EDAIESVPYL ASDEKGSNYK EATQIPLNLK QSEIENHPTV KPWVHFVAGG 
61:	IGGMAGAVVT CPFDLVKTRL QSDIFLKAYK SQAVNISKGS TRPKSINYVI QAGTHFKETL 
121:	GIIGNVYKQE GFRSLFKGLG PNLVGVIPAR SINFFTYGTT KDMYAKAFNN GQETPMIHLM 
181:	AAATAGWATA TATNPIWLIK TRVQLDKAGK TSVRQYKNSW DCLKSVIRNE GFTGLYKGLS 
241:	ASYLGSVEGI LQWLLYEQMK RLIKERSIEK FGYQAEGTKS TSEKVKEWCQ RSGSAGLAKF 
301:	VASIATYPHE VVRTRLRQTP KENGKRKYTG LVQSFKVIIK EEGLFSMYSG LTPHLMRTVP 
361:	NSIIMFGTWE IVIRLLS