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2.A.29.10.5
The mitochondrial NAD+ uptake transporter, Ndt1 (also transports (d)AMP and (d)GMP but not α-NAD+, NADH, NADP+, or NADPH. Transport is saturable with an apparent Km of 0.38mM for NAD+). (70% identical to Ndt2 which also takes up NAD+). The main role of Ndt1p and Ndt2p is to import NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated (d)AMP and (d)GMP (Todisco et al., 2006)

Accession Number:P40556
Protein Name:Putative mitochondrial carrier YIL006W
Length:373
Molecular Weight:41954.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate NAD+, AMP, GMP

Cross database links:

Genevestigator: P40556
eggNOG: fuNOG04711
HEGENOM: HBG735918
DIP: DIP-4960N
RefSeq: NP_012260.1   
Entrez Gene ID: 854811   
Pfam: PF00153   
KEGG: sce:YIL006W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0051724 F:NAD transporter activity
GO:0005477 F:pyruvate secondary active transmembrane tra...
GO:0006850 P:mitochondrial pyruvate transport
GO:0043132 P:NAD transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.”  Churcher C.M.et.al.   9169870
[2] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTQTDNPVPN CGLLPEQQYC SADHEEPLLL HEEQLIFPDH SSQLSSADII EPIKMNSSTE 
61:	SIIGTTLRKK WVPLSSTQIT ALSGAFAGFL SGVAVCPLDV AKTRLQAQGL QTRFENPYYR 
121:	GIMGTLSTIV RDEGPRGLYK GLVPIVLGYF PTWMIYFSVY EFSKKFFHGI FPQFDFVAQS 
181:	CAAITAGAAS TTLTNPIWVV KTRLMLQSNL GEHPTHYKGT FDAFRKLFYQ EGFKALYAGL 
241:	VPSLLGLFHV AIHFPIYEDL KVRFHCYSRE NNTNSINLQR LIMASSVSKM IASAVTYPHE 
301:	ILRTRMQLKS DIPDSIQRRL FPLIKATYAQ EGLKGFYSGF TTNLVRTIPA SAITLVSFEY 
361:	FRNRLENIST MVI