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2.A.29.12.2
Mitochondrial exchange transporter for Coenzyme A and adenosine 3', 5'-diphosphate, SLC25A42 (also transports dephospho-Coenzyme A, and ADP; Fiermonte et al. 2009).

Accession Number:Q86VD7
Protein Name:Solute carrier family 25 member 42
Length:318
Molecular Weight:35409.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Coenzyme A, ADP

Cross database links:

NOG274055
Genevestigator: Q86VD7 Q86VD7
HEGENOM: HBG735918 HOG000165726
RefSeq: NP_848621.2   
Entrez Gene ID: 284439   
Pfam: PF00153   
OMIM: 610823  gene
KEGG: hsa:284439    hsa:284439   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport
GO:0005739 C:mitochondrion
GO:0043262 F:adenosine-diphosphatase activity
GO:0015217 F:ADP transmembrane transporter activity
GO:0080122 F:AMP transmembrane transporter activity
GO:0005347 F:ATP transmembrane transporter activity
GO:0015228 F:coenzyme A transmembrane transporter activity

References (8)

[1] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[4] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866
[5] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[8] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.”  Imami K.et.al.   18187866

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNGVKEGPV RLHEDAEAVL SSSVSSKRDH RQVLSSLLSG ALAGALAKTA VAPLDRTKII 
61:	FQVSSKRFSA KEAFRVLYYT YLNEGFLSLW RGNSATMVRV VPYAAIQFSA HEEYKRILGS 
121:	YYGFRGEALP PWPRLFAGAL AGTTAASLTY PLDLVRARMA VTPKEMYSNI FHVFIRISRE 
181:	EGLKTLYHGF MPTVLGVIPY AGLSFFTYET LKSLHREYSG RRQPYPFERM IFGACAGLIG 
241:	QSASYPLDVV RRRMQTAGVT GYPRASIART LRTIVREEGA VRGLYKGLSM NWVKGPIAVG 
301:	ISFTTFDLMQ ILLRHLQS