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2.A.29.12.3
solute carrier family 25; mitochondrial carrier; Graves disease autoantigen, member 16.  It is a Coenzyme A transporter (Gutiérrez-Aguilar and Baines 2013).

Accession Number:P16260
Protein Name:Graves disease carrier protein
Length:332
Molecular Weight:36224.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate CoA

Cross database links:

Genevestigator: P16260 P16260
eggNOG: NOG274055 NOG274055
HEGENOM: HOG000165726 HOG000165726
Entrez Gene ID: 8034   
Pfam: PF00153   
KEGG: hsa:8034    hsa:8034   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0015300 F:solute:solute antiporter activity
GO:0009108 P:coenzyme biosynthetic process
GO:0015939 P:pantothenate metabolic process

References (12)

[1] “Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins.”  Zarrilli R.et.al.   2575220
[2] “Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease.”  Fiermonte G.et.al.   1457817
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix.”  Prohl C.et.al.   11158296
[7] “Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins.”  Zarrilli R.et.al.   2575220
[8] “Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease.”  Fiermonte G.et.al.   1457817
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix.”  Prohl C.et.al.   11158296

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV 
61:	KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL 
121:	ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA 
181:	KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT 
241:	HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL 
301:	YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN