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2.A.29.12.4
Mitochondrial Coenzyme A carrier protein, LEU5 or Leu-5 (Gutiérrez-Aguilar and Baines 2013).

Accession Number:P38702
Protein Name:Mitochondrial carrier protein LEU5
Length:357
Molecular Weight:40825.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Coenzyme A

Cross database links:

Genevestigator: P38702
eggNOG: NOG274055
HEGENOM: HOG000165726
DIP: DIP-8164N
Entrez Gene ID: 856391   
Pfam: PF00153   
KEGG: sce:YHR002W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015228 F:coenzyme A transmembrane transporter activity

References (2)

[1] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[2] “The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix.”  Prohl C.et.al.   11158296

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL IAPLDRIKIL 
61:	FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA TLLRIFPYAA VKFVAYEQIR 
121:	NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT YPLDLVRVRL AYETEHKRVK LGRIIKKIYK 
181:	EPASATLIKN DYIPNWFCHW CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY 
241:	SVLELSEDDE LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK 
301:	TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER MKWNFGI