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2.A.29.14.1
Mitochondrial Ca2+-activated aspartate/glutamate antiporter carrier with Ca2+-binding EF-hand domain, Aralar

Accession Number:O75746
Protein Name:CMC1 aka SLC25A12 aka ARALAR1
Length:678
Molecular Weight:74762.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate

Cross database links:

Genevestigator: O75746 O75746
eggNOG: prNOG04936 NOG292991
HEGENOM: HBG357440 HOG000180633
RefSeq: NP_003696.2   
Entrez Gene ID: 8604   
Pfam: PF00153   
OMIM: 603667  gene
KEGG: hsa:8604    hsa:8604   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005509 F:calcium ion binding
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015810 P:aspartate transport
GO:0015813 P:L-glutamate transport
GO:0043490 P:malate-aspartate shuttle
GO:0051592 P:response to calcium ion
GO:0055085 P:transmembrane transport
GO:0006094 P:gluconeogenesis

References (12)

[1] “Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain.”  Del Arco A.et.al.   9722566
[2] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.”  Palmieri L.et.al.   11566871
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.”  Kobayashi K.et.al.   10369257
[6] “Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain.”  Del Arco A.et.al.   9722566
[7] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.”  Palmieri L.et.al.   11566871
[8] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.”  Kobayashi K.et.al.   10369257
[11] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[12] “AGC1 deficiency associated with global cerebral hypomyelination.”  Wibom R.et.al.   19641205
Structure:
4P5X   4P60     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVKVQTTKR GDPHELRNIF LQYASTEVDG ERYMTPEDFV QRYLGLYNDP NSNPKIVQLL 
61:	AGVADQTKDG LISYQEFLAF ESVLCAPDSM FIVAFQLFDK SGNGEVTFEN VKEIFGQTII 
121:	HHHIPFNWDC EFIRLHFGHN RKKHLNYTEF TQFLQELQLE HARQAFALKD KSKSGMISGL 
181:	DFSDIMVTIR SHMLTPFVEE NLVSAAGGSI SHQVSFSYFN AFNSLLNNME LVRKIYSTLA 
241:	GTRKDVEVTK EEFAQSAIRY GQVTPLEIDI LYQLADLYNA SGRLTLADIE RIAPLAEGAL 
301:	PYNLAELQRQ QSPGLGRPIW LQIAESAYRF TLGSVAGAVG ATAVYPIDLV KTRMQNQRGS 
361:	GSVVGELMYK NSFDCFKKVL RYEGFFGLYR GLIPQLIGVA PEKAIKLTVN DFVRDKFTRR 
421:	DGSVPLPAEV LAGGCAGGSQ VIFTNPLEIV KIRLQVAGEI TTGPRVSALN VLRDLGIFGL 
481:	YKGAKACFLR DIPFSAIYFP VYAHCKLLLA DENGHVGGLN LLAAGAMAGV PAASLVTPAD 
541:	VIKTRLQVAA RAGQTTYSGV IDCFRKILRE EGPSAFWKGT AARVFRSSPQ FGVTLVTYEL 
601:	LQRWFYIDFG GLKPAGSEPT PKSRIADLPP ANPDHIGGYR LATATFAGIE NKFGLYLPKF 
661:	KSPSVAVVQP KAAVAATQ