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2.A.29.14.4
Yeast mitochondrial aspartate/glutamate antiporter, Agc1 (Cavero et al., 2003) (also catalyzes glutamate uniport and glutamate:proton symport (Palmieri et al. 2006). Comprised of 902 aas; has a 500 residue N-terminal hydrophilic domain as well as a C-terminal 100 residue hydrophilic domain. Both domains are uniquely found in members of the 2.A.29.14 subfamily.

Accession Number:Q12482
Protein Name:Agc1p
Length:902
Molecular Weight:104304.00
Species:Saccharomyces cerevisiae [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate glutamate, aspartate

Cross database links:

Genevestigator: Q12482
eggNOG: fuNOG04995
HEGENOM: HBG203953
DIP: DIP-8968N
RefSeq: NP_015346.1   
Entrez Gene ID: 856132   
Pfam: PF00153   
KEGG: sce:YPR021C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015297 F:antiporter activity
GO:0005488 F:binding
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0015292 F:uniporter activity
GO:0015810 P:aspartate transport
GO:0044271 P:cellular nitrogen compound biosynthetic pro...
GO:0015813 P:L-glutamate transport
GO:0055085 P:transmembrane transport

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[2] “Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.”  el Moualij B.et.al.   9178508
[3] “Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae.”  Cavero S.et.al.   14622413
[4] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEQINSNSRK KKQQLEVFKY FASVLTKEDK PISISNGMLD MPTVNSSKLT AGNGKPDTEK 
61:	LTGELILTYD DFIELISSSK TIYSKFTDHS FNLNQIPKNV FGCIFFAIDE QNKGYLTLND 
121:	WFYFNNLLEY DNYHLIILYE FFRKFDVENL KAKQKKELGS SSFNLKAADD RIKSINYGNR 
181:	FLSFDDLLLN LNQFKDTIRL LHESIDDNFV KDNKLLLDWN DFRFLKFYKC YHENEEYLSL 
241:	NSLVTILQND LKNEKIFIGF DRLAQMDSQG HRLALSKNQL TYLLRLFYSH RVSADIFSSL 
301:	NLSNTELLKA DNNSIPYNVF KDIFYLFQNF DLLNQIFHKY VTENNLNEQD IREQIVTKND 
361:	FMTVLNAQYN KVNNIIEFSP SQINLLFSIV ANSKENRRLR KRNQDRDDEL LNDHHYDSDI 
421:	DFFIHNEYLH GVSRSRKNLE SFNDYYHDLS DGFDQDSGVK KASKASTGLF ESVFGGKKDK 
481:	ATMRSDLTIE DFMKILNPNY LNDLVHQMEL QKNQNESLYI NYYFYPIFDS LYNFSLGSIA 
541:	GCIGATVVYP IDFIKTRMQA QRSLAQYKNS IDCLLKIISR EGIKGLYSGL GPQLIGVAPE 
601:	KAIKLTVNDF MRNRLTDKNG KLSLFPEIIS GASAGACQVI FTNPLEIVKI RLQVQSDYVG 
661:	ENIQQANETA TQIVKKLGLR GLYNGVAACL MRDVPFSAIY FPTYAHLKKD LFDFDPNDKT 
721:	KRNRLKTWEL LTAGAIAGMP AAFLTTPFDV IKTRLQIDPR KGETKYNGIF HAIRTILKEE 
781:	SFRSFFKGGG ARVLRSSPQF GFTLAAYELF KGFIPSPDNK LKSREGRKRF CIDDDAGNEE 
841:	TVVHSNGELP QQKFYSDDRK HANYYYKSCQ IAKTFIDLDN NFSRFDSSVY KNFQEHLRSI 
901:	NG