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2.A.29.14.5
solute carrier family 25 (glutamate carrier), member 18

Accession Number:Q9H1K4
Protein Name:Mitochondrial glutamate carrier 2
Length:315
Molecular Weight:33849.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate glutamate

Cross database links:

Genevestigator: Q9H1K4 Q9H1K4
eggNOG: NOG276269 NOG276269
HEGENOM: HOG000168308 HOG000168308
Entrez Gene ID: 83733   
Pfam: PF00153   
Drugbank: Drugbank Link   
KEGG: hsa:83733    hsa:83733   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0015293 F:symporter activity

References (8)

[1] “Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.”  Fiermonte G.et.al.   11897791
[2] “Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.”  Footz T.K.et.al.   11381032
[3] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.”  Fiermonte G.et.al.   11897791
[6] “Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.”  Footz T.K.et.al.   11381032
[7] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTHQDLSITA KLINGGVAGL VGVTCVFPID LAKTRLQNQH GKAMYKGMID CLMKTARAEG 
61:	FFGMYRGAAV NLTLVTPEKA IKLAANDFFR RLLMEDGMQR NLKMEMLAGC GAGMCQVVVT 
121:	CPMEMLKIQL QDAGRLAVHH QGSASAPSTS RSYTTGSAST HRRPSATLIA WELLRTQGLA 
181:	GLYRGLGATL LRDIPFSIIY FPLFANLNNL GFNELAGKAS FAHSFVSGCV AGSIAAVAVT 
241:	PLDVLKTRIQ TLKKGLGEDM YSGITDCARK LWIQEGPSAF MKGAGCRALV IAPLFGIAQG 
301:	VYFIGIGERI LKCFD