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2.A.29.14.6
solute carrier family 25, member 40.  This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013).  May also be involved in  primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).

Accession Number:Q8TBP6
Protein Name:Solute carrier family 25 member 40
Length:338
Molecular Weight:38125.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q8TBP6 Q8TBP6
eggNOG: NOG276989 NOG276989
HEGENOM: HOG000214473 HOG000214473
Entrez Gene ID: 55972   
Pfam: PF00153   
KEGG: hsa:55972    hsa:55972   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (10)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[8] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL PKGKCFVYSN 
61:	GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI KSLWSGLPPT LVMAVPATVI 
121:	YFTCYDQLSA LLRSKLGENE TCIPIVAGIV ARFGAVTVIS PLELIRTKMQ SKKFSYVELH 
181:	RFVSKKVSED GWISLWRGWA PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT 
241:	SGALSGSFAA VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF 
301:	SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY