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2.A.29.16.1
Reported to be a deoxynucleotide (enzyme), the deoxynucleotide carrier (DNT) (all four dNDPs and less efficiently, all four dNTPs are transported, but not dNMPs, NMPs or nucleosides). It is also a thiamin pyrophosphate (TPP) transporter responsible for Amish lethal microencephaly brain development retardation (MCPHA) and α-ketoglutarate acidurua when defective (Arco and Satrústegui, 2005; Lindhurst et al., 2006; Iacopetta et al., 2010).

Accession Number:Q9HC21
Protein Name:DNT aka SLC25A19 aka DNC aka MUP1
Length:320
Molecular Weight:35511.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate dNDPs, dNTPs

Cross database links:

NOG310116
Genevestigator: Q9HC21 Q9HC21
HEGENOM: HBG735918 HOG000165726
RefSeq: NP_001119593.1    NP_001119594.1    NP_068380.3   
Entrez Gene ID: 60386   
Pfam: PF00153   
OMIM: 606521  gene
607196  phenotype
KEGG: hsa:60386    hsa:60386   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0030233 F:deoxynucleotide transmembrane transporter a...
GO:0030302 P:deoxynucleotide transport
GO:0055085 P:transmembrane transport
GO:0030233 F:deoxynucleotide transmembrane transporter activity

References (10)

[1] “The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals.”  Dolce V.et.al.   11226231
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier.”  Kang J.et.al.   18280798
[4] “Mutant deoxynucleotide carrier is associated with congenital microcephaly.”  Rosenberg M.J.et.al.   12185364
[5] “The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals.”  Dolce V.et.al.   11226231
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier.”  Kang J.et.al.   18280798
[8] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[9] “Mutant deoxynucleotide carrier is associated with congenital microcephaly.”  Rosenberg M.J.et.al.   12185364
[10] “SLC25A19 mutation as a cause of neuropathy and bilateral striatal necrosis.”  Spiegel R.et.al.   19798730

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVGYDPKPDG RNNTKFQVAV AGSVSGLVTR ALISPFDVIK IRFQLQHERL SRSDPSAKYH 
61:	GILQASRQIL QEEGPTAFWK GHVPAQILSI GYGAVQFLSF EMLTELVHRG SVYDAREFSV 
121:	HFVCGGLAAC MATLTVHPVD VLRTRFAAQG EPKVYNTLRH AVGTMYRSEG PQVFYKGLAP 
181:	TLIAIFPYAG LQFSCYSSLK HLYKWAIPAE GKKNENLQNL LCGSGAGVIS KTLTYPLDLF 
241:	KKRLQVGGFE HARAAFGQVR RYKGLMDCAK QVLQKEGALG FFKGLSPSLL KAALSTGFMF 
301:	FSYEFFCNVF HCMNRTASQR