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2.A.29.16.2
The thiamin pyrophosphate (TPP) transporter, Tpc1; catalyzes thiamin pyrophosphate/thiamin monophosphate excange (Palmieri et al. 2006).  Also transports pyrophosphate, ADP, ATP and other nucleotides (Iacopetta et al., 2010).

Accession Number:Q7K0L7
Protein Name:CG6608, isoform A
Length:332
Molecular Weight:36678.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate thiamin pyrophosphate, pyrophosphate, ATP, ADP

Cross database links:

eggNOG: inNOG06252
RefSeq: NP_650034.1    NP_731527.1   
Entrez Gene ID: 41316   
Pfam: PF00153   
KEGG: dme:Dmel_CG6608   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAVTTGSTSE ATTTTTPVPR RKHSTREQLH QMLAGGLSAA ITRSTCQPLD VLKIRFQLQV 
61:	EPLGKNAAKE GPGALTSKYT SIGQAVKTIY REEGMLAFWK GHNPAQVLSI MYGICQFWTY 
121:	EQLSLMAKQT SYLADHQHLS NFLCGAAAGG AAVIISTPLD VIRTRLIAQD TSKGYRNATR 
181:	AVSAIVRQEG PRGMYRGLSS ALLQITPLMG TNFMAYRLFS DWACAFLEVS DRSQLPTWTL 
241:	LGLGASSGML SKTIVYPFDL IKKRLQIQGF ESNRQTFGQT LQCHGVWDCL RLTVRQEGVR 
301:	GLYKGVAPTL LKSSMTTALY FSIYDKLKQV RF