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2.A.29.18.3
solute carrier family 25 (S-adenosylmethionine carrier), member 26

Accession Number:Q70HW3
Protein Name:S-adenosylmethionine mitochondrial carrier protein
Length:274
Molecular Weight:29381.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate S-adenosylmethionine

Cross database links:

Genevestigator: Q70HW3 Q70HW3
eggNOG: NOG247316 NOG247316
HEGENOM: HOG000038810 HOG000038810
Entrez Gene ID: 115286   
Pfam: PF00153   
KEGG: hsa:115286    hsa:115286   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005634 C:nucleus
GO:0000095 F:S-adenosylmethionine transmembrane transporter activity

References (6)

[1] “Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.”  Agrimi G.et.al.   14674884
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.”  Agrimi G.et.al.   14674884
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY AGVPSAAIGS 
61:	FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV VACLIRVPSE VVKQRAQVSA 
121:	STRTFQIFSN ILYEEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDHVVDSW 
181:	QSAVCGAFAG GFAAAVTTPL DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG 
241:	VFPRMAAISL GGFIFLGAYD RTHSLLLEVG RKSP