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2.A.29.2.13
Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)

Accession Number:Q02978
Protein Name:Mitochondrial 2-oxoglutarate/malate carrier protein
Length:314
Molecular Weight:34062.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate 2-oxoglutarate, malate

Cross database links:

Genevestigator: Q02978
eggNOG: NOG300113
HEGENOM: HOG000165139
Entrez Gene ID: 8402   
Pfam: PF00153   
KEGG: hsa:8402   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015367 F:oxoglutarate:malate antiporter activity
GO:0006094 P:gluconeogenesis

References (5)

[1] “Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier.”  Iacobazzi V.et.al.   1457818
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[4] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[5] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGEGAKTRE 
61:	YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG IYTVLFERLT GADGTPPGFL 
121:	LKAVIGMTAG ATGAFVGTPA EVALIRMTAD GRLPADQRRG YKNVFNALIR ITREEGVLTL 
181:	WRGCIPTMAR AVVVNAAQLA SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV 
241:	DIAKTRIQNM RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 
301:	EQMNKAYKRL FLSG